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Golotimod hydrochloride

Name: Golotimod hydrochloride
Brand: TargetMol
SKU: T11449
Price: 534 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11449Cas No. 1029401-59-9

Alias SCV07 hydrochloride, SCV 07 hydrochloride, Golotimod hydrochloride (229305-39-9 free base), Gamma-D-glutamyl-L-tryptophan hydrochloride

Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulatory peptide with antibacterial activity that inhibits the homodimerization of STAT3 in the cytoplasm, thereby inhibiting STAT3 signaling. It can be used for studying immune-sensitive diseases and HCV infections.

Golotimod hydrochloride

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Purity: 99.86%

Catalog No. T11449Alias SCV07 hydrochloride, SCV 07 hydrochloride, Golotimod hydrochloride (229305-39-9 free base), Gamma-D-glutamyl-L-tryptophan hydrochlorideCas No. 1029401-59-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$98	-	In Stock
10 mg	$159	-	In Stock
50 mg	$398	Inquiry	Inquiry
100 mg	$534	Inquiry	Inquiry
200 mg	Inquiry	Inquiry	Inquiry
500 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulatory peptide with antibacterial activity that inhibits the homodimerization of STAT3 in the cytoplasm, thereby inhibiting STAT3 signaling. It can be used for studying immune-sensitive diseases and HCV infections.
In vitro	Golotimod hydrochloride can stimulate T helper cells to shift to TH1-like immune response. Golotimod hydrochloride can stimulate macrophage function decreased by TB infection and isoniazid treatment, and improve phagocytosis activity of peritoneal macrophages. It can be used as a prospective immunomodulator for the complex treatment of tuberculosis (TB). [1]
In vivo	Oral administration of Golotimod hydrochloride at a dose of 5μg/kg after fasting overnight significantly reduced infectional recurrent lesions in recurrent genital HSV-2 guinea pigs. [2] Golotimod hydrochloride is able to alter the duration and severity of oral mucositis and depends on time and dose.
Synonyms	SCV07 hydrochloride, SCV 07 hydrochloride, Golotimod hydrochloride (229305-39-9 free base), Gamma-D-glutamyl-L-tryptophan hydrochloride

Chemical Properties

Molecular Weight	369.8
Formula	C₁₆H₂₀ClN₃O₅
Cas No.	1029401-59-9
Smiles	C([C@@H](NC(CC[C@H](C(O)=O)N)=O)C(O)=O)C=1C=2C(NC1)=CC=CC2.Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 120 mg/mL (324.5 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7042 mL	13.5208 mL	27.0416 mL	135.2082 mL
5 mM	0.5408 mL	2.7042 mL	5.4083 mL	27.0416 mL
10 mM	0.2704 mL	1.3521 mL	2.7042 mL	13.5208 mL
20 mM	0.1352 mL	0.6760 mL	1.3521 mL	6.7604 mL
50 mM	0.0541 mL	0.2704 mL	0.5408 mL	2.7042 mL
100 mM	0.0270 mL	0.1352 mL	0.2704 mL	1.3521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc