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SQ-31765

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Catalog No. T12993Cas No. 138383-07-0

SQ-31765 is a blocker of benzazepine calcium channel.

SQ-31765

SQ-31765

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Catalog No. T12993Cas No. 138383-07-0
SQ-31765 is a blocker of benzazepine calcium channel.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,6706-8 weeks6-8 weeks
50 mg$2,1806-8 weeks6-8 weeks
100 mg$2,8006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
SQ-31765 is a blocker of benzazepine calcium channel.
In vivo
SQ-31765 (SQ 31,765) effectively mitigates ischemia severity independent of myocardial blood flow or hemodynamic changes. In a study, anesthetized dogs were administered saline (n=6), SQ-31765 (n=6; 0.2 mg/kg), or SQ 32,189 (n=6; 0.2 mg/kg) intravenously 10 minutes before inducing ischemia. The study examined the compound's impact on pacing-induced ST-segment elevation and myocardial blood flow during left anterior descending coronary artery stenosis. SQ-31765 significantly reduced ST-segment elevation (P<0.05) at 10, 40, and 70 minutes post-infusion, showing a notable reduction (5.9±1.4 mV at 70 minutes) compared to the saline group (12.0±1.4 mV at 70 minutes). All test groups exhibited decreased subendocardial flow due to left anterior descending coronary artery stenosis during atrial pacing before drug administration, highlighting SQ-31765's protective effects against pacing-induced myocardial injury.
Chemical Properties
Molecular Weight464.48
FormulaC24H27F3N2O4
Cas No.138383-07-0
SmilesC(F)(F)(F)C1=C2C(N(CCN(C)C)C(=O)[C@H](OC(C)=O)[C@@H](C2)C3=CC=C(OC)C=C3)=CC=C1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SQ-31765SQ31765SQ 31765CalciumChannelCalcium Channel
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