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Orexin A (human, rat, mouse) acetate
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Catalog No. T73658
Alias Hypocretin-1 (human, rat, mouse) acetate
Orexin A (human, rat, mouse) acetate (Hypocretin-1) is an excitatory neuropeptide with analgesic properties. It activates Orexin-1 (OX1R) and Orexin-2 (OX2R) receptors, used for studying neurodegenerative diseases.
Orexin A (human, rat, mouse) acetate
Orexin A (human, rat, mouse) acetate
🥰Excellent
Catalog No. T73658Alias Hypocretin-1 (human, rat, mouse) acetate
Orexin A (human, rat, mouse) acetate (Hypocretin-1) is an excitatory neuropeptide with analgesic properties. It activates Orexin-1 (OX1R) and Orexin-2 (OX2R) receptors, used for studying neurodegenerative diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $106 | - | In Stock | |
| 5 mg | $262 | - | In Stock | |
| 10 mg | $419 | - | In Stock | |
| 25 mg | $795 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Orexin A (human, rat, mouse) acetate (Hypocretin-1) is an excitatory neuropeptide with analgesic properties. It activates Orexin-1 (OX1R) and Orexin-2 (OX2R) receptors, used for studying neurodegenerative diseases. |
| In vitro | Orexin A (human, rat, mouse) acetate (0.1, 1, 10, 100 nM, 24h) increased the expression of BDNF in SH-SY5Y human dopaminergic neuroblastoma cells. [1] Orexin A (human, rat, mouse) acetate (5μM) therapy alleviated the decrease in the number of MC3T3-E1 cells and OCN expression induced by chronic intermittent hypoxia (CIH) by combining with OX1R. [2] |
| In vivo | Orexin A (human, rat, mouse) acetate(300 ng/ mouse, injected into the brain) significantly improved spatial learning and memory impairment in MPTP-induced Parkinson's disease mouse models. [1] Orexin A (human, rat, mouse) acetate treatment improved bone formation in CIH mice. [2] |
| Synonyms | Hypocretin-1 (human, rat, mouse) acetate |
| Molecular Weight | 3621.15 |
| Formula | C154H247N47O46S4 |
| Color | White |
| Appearance | Solid |
| Sequence Short | {Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: 40 mg/mL (11.05 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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