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BI-9321 trihydrochloride

Name: BI-9321 trihydrochloride
Brand: TargetMol
SKU: T10538L
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10538LCas No. 2387510-87-2

Alias BI9321 trihydrochloride, BI9321 3HCl

BI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.

BI-9321 trihydrochloride

🥰Excellent

Purity: 99.34%

Catalog No. T10538LAlias BI9321 trihydrochloride, BI9321 3HClCas No. 2387510-87-2

BI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$189	In Stock	In Stock
25 mg	$372	In Stock	In Stock
50 mg	$629	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.34%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
Targets&IC50	U2OS cells:1.2 μM
In vitro	BI-9321 trihydrochloride specifically interfered with the interaction between the NSD3-PWWP1 structural domain and histones, with an IC50=1.2 μM in U2OS cells. BI-9321 trihydrochloride targeted the methyl lysine binding site of the PWWP1 structural domain and effectively bound its intracellular target at 1 µM concentration. In addition, BI-9321 trihydrochloride significantly down-regulated the expression of Myc mRNA and reduced the proliferation of MOLM-13 cells. [1]
Synonyms	BI9321 trihydrochloride, BI9321 3HCl

Chemical Properties

Molecular Weight	469.81
Formula	C₂₂H₂₄Cl₃FN₄
Cas No.	2387510-87-2
Smiles	FC1=CC=C2C(N=CC=C2C3=C(C4=C(C)C=C(CN)C=C4C)N=CN3C)=C1.Cl.Cl.Cl
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL(42.57 mM), Sonication is recommended.

DMSO: 200 mg/mL(425.70 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1285 mL	10.6426 mL	21.2852 mL	106.4260 mL
5 mM	0.4257 mL	2.1285 mL	4.2570 mL	21.2852 mL
10 mM	0.2129 mL	1.0643 mL	2.1285 mL	10.6426 mL
20 mM	0.1064 mL	0.5321 mL	1.0643 mL	5.3213 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0426 mL	0.2129 mL	0.4257 mL	2.1285 mL
100 mM	0.0213 mL	0.1064 mL	0.2129 mL	1.0643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc