Shopping Cart

Your shopping cart is currently empty

JNJ-31020028

Name: JNJ-31020028
Brand: TargetMol
SKU: T1997
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T1997Cas No. 1094873-14-9

Alias JNJ 31020028

JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors.

JNJ-31020028

Copy Product Info

😃Good

Purity: 99.65%

Catalog No. T1997Alias JNJ 31020028Cas No. 1094873-14-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$130	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$333	-	In Stock
200 mg	$478	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.65%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

JNJ-31020028 AI Summary

JNJ-31020028 exhibits significant bioactivity as a Y2 receptor antagonist, evidenced by its ability to displace [125I]PYY from the human NPY Y2 receptor with an IC50 value of 6.0 nM. This suggests its potential for modulating the neuropeptide Y (NPY) pathway, which is involved in numerous physiological processes, including appetite regulation, stress response, and cardiovascular function. In vivo studies show it has an ED50 of 1.6 mg/kg for NPYY5 receptor occupancy in rat brain, with 90% activity observed at 10 mg/kg. The compound also demonstrates high selectivity for NPYY5, NPYY4, and NPYY1 receptors. However, it shows low metabolic stability, with only 1.7% and 1.4% remaining after 15 minutes in rat and human liver microsomes, respectively. Additionally, JNJ-31020028 exhibits moderate inhibitory activity against MTP with an IC50 value of 710.0 nM. Pharmacokinetic properties include a half-life of 0.83 hours, a Cmax of 4350.0 nM, 100% bioavailability when administered subcutaneously at 10 mg/kg, and 6.0% oral bioavailability in rats. In terms of antiviral activity, JNJ-31020028 shows limited inhibition of SARS-CoV-2 3CL-Pro protease and VERO-6 cell cytotoxicity, with 4.52% inhibition at 20 µM and 0.31% at 10 µM after 48 hours, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors.
Targets&IC50	Y2 receptor (human):8.07(pIC50), Y2 receptor (rat):8.22(pIC50)
Synonyms	JNJ 31020028

Chemical Properties

Molecular Weight	565.68
Formula	C₃₄H₃₆FN₅O₂
Cas No.	1094873-14-9
Smiles	CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Relative Density.	1.228 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.66 mg/mL (10.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7678 mL	8.8389 mL	17.6778 mL	88.3892 mL
5 mM	0.3536 mL	1.7678 mL	3.5356 mL	17.6778 mL
10 mM	0.1768 mL	0.8839 mL	1.7678 mL	8.8389 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc