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Ursolic acid acetate

Name: Ursolic acid acetate
Brand: TargetMol
SKU: T3819
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3819Cas No. 7372-30-7

Alias Acetylursolic acid, 3-Acetylursolic Acid

Ursolic acid acetate (Acetylursolic acid) has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities. Acetylursolic acid has inhibition against both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes.

Ursolic acid acetate

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Purity: 98.3%

Catalog No. T3819Alias Acetylursolic acid, 3-Acetylursolic AcidCas No. 7372-30-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$152	In Stock	In Stock
10 mg	$247	In Stock	In Stock
25 mg	$422	In Stock	In Stock
50 mg	$613	In Stock	In Stock
100 mg	$869	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.3%

Resource Download

COA HNMR LCMS

Product Introduction

Ursolic acid acetate AI Summary

Ursolic acid acetate exhibits a diverse range of bioactivities across various assays. It displays antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 with an IC50 of 24930.0 nM after 24 hours and a similarly significant effect against Plasmodium falciparum Dd2 under low oxygen conditions with an IC50 of 12090.0 nM. The compound also shows antiplasmodial activity against Plasmodium falciparum W2 in human erythrocytes with an IC50 of 9080.0 nM, alongside cytotoxicity against Vero and HepG2 cells, with CC50 values greater than 400,000.0 nM. In terms of antiproliferative activity, Ursolic acid acetate inhibits human HeLa cells, showing a moderate effect with an IC50 over 10,000.0 nM. The compound further exhibits cytotoxicity against human NTUB1 cells (IC50: 14270.0 nM), AsPC1 cells (IC50: 71000.0 nM), and against several other human cancer cell lines including HT-29, HepG2, BGC823, and GES-1. Ursolic acid acetate is a potent inhibitor in biochemical assays, inhibiting aromatase activity with an IC50 of 42.7 µg/mL, beta-hematin formation, and various other targets like RecQ-Like DNA Helicase 1 (IC50: 562.3 nM) and rabbit muscle glycogen phosphorylase A. It also exhibits inhibitory activity against TDP1, Top1, and SENP1 enzymes while showing selective inhibitory effects with potential implications for anti-cancer activities. Additionally, Ursolic acid acetate demonstrates antitrypanosomal activities against Trypanosoma cruzi and Trypanosoma brucei, with IC50 values greater than 32000.0 nM and 17000.0 nM, respectively, and an antiparasitic effect against Toxoplasma gondii with an IC50 of 7900.0 nM. Furthermore, the compound exhibits cytotoxicity profiles against other pathogens such as Streptococcus and Group A Streptococcus. In summary, Ursolic acid acetate is a multifaceted compound with activities ranging from antiparasitic and antimalarial to antiproliferative and enzyme inhibition, highlighting its potential as a therapeutic candidate in various fields of disease treatment..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ursolic acid acetate (Acetylursolic acid) has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities. Acetylursolic acid has inhibition against both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes.
Synonyms	Acetylursolic acid, 3-Acetylursolic Acid

Chemical Properties

Molecular Weight	498.74
Formula	C₃₂H₅₀O₄
Cas No.	7372-30-7
Smiles	C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)C5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
Relative Density.	1.09 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (24.06 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0051 mL	10.0253 mL	20.0505 mL	100.2526 mL
5 mM	0.4010 mL	2.0051 mL	4.0101 mL	20.0505 mL
10 mM	0.2005 mL	1.0025 mL	2.0051 mL	10.0253 mL
20 mM	0.1003 mL	0.5013 mL	1.0025 mL	5.0126 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc