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M-CSF/CSF1 Protein, Human, Recombinant

Catalog No. TMPY-00127
Synonyms: CSF-1, MCSF, M-CSF, colony stimulating factor 1 (macrophage)

M-CSF/CSF1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.4 kDa and the accession number is P09603-2.

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M-CSF/CSF1 Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
20 μg In stock $ 275.00
100 μg 5 days $ 773.00
1 mg 5 days $ 5,030.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is typically 1.6-6.3 ng/mL.
Description M-CSF/CSF1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.4 kDa and the accession number is P09603-2.
Species Human
Expression System HEK293 Cells
Tag Tag Free
Accession Number P09603-2
Synonyms CSF-1, MCSF, M-CSF, colony stimulating factor 1 (macrophage)
Construction The Human CSF1 (NP_757349.1) (Met1-Asn190) was expressed with an initial Met.
Protein Purity > 85 % as determined by SDS-PAGE.
Molecular Weight 18.4 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution Reconstituted with sterile deionized water to 0.25 mg/mL.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.

References and Literature

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Keywords

M-CSF/CSF1 Protein, Human, Recombinant CSF-1 CSF1 CSF 1 MCSF M-CSF colony stimulating factor 1 (macrophage) colony stimulating factor 1 macrophage recombinant recombinant-proteins proteins protein

 

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