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Chloroquinoxaline sulfonamide

Name: Chloroquinoxaline sulfonamide
Brand: TargetMol
SKU: T14953
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T14953Cas No. 97919-22-7

Alias NSC-339004, Chloroquinoxaline

Chloroquinoxaline sulfonamide (Chloroquinoxaline) is a topoisomerase II alpha/beta toxin with antitumor activity and immunosuppressive properties that inhibits the proliferation of B16 melanoma cells in mice, and can be used to study metastatic colorectal cancer. It can be used to study metastatic colorectal cancer.

Chloroquinoxaline sulfonamide

🥰Excellent

Purity: 99.89%

Catalog No. T14953Alias NSC-339004, ChloroquinoxalineCas No. 97919-22-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	In Stock	In Stock
5 mg	$128	In Stock	In Stock
10 mg	$187	In Stock	In Stock
25 mg	$312	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$678	In Stock	In Stock
500 mg	$1,430	-	In Stock
1 mL x 10 mM (in DMSO)	$138	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.89%

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COA LCMS

Product Introduction

Bioactivity

Description	Chloroquinoxaline sulfonamide (Chloroquinoxaline) is a topoisomerase II alpha/beta toxin with antitumor activity and immunosuppressive properties that inhibits the proliferation of B16 melanoma cells in mice, and can be used to study metastatic colorectal cancer. It can be used to study metastatic colorectal cancer.
Targets&IC50	CV-1 cells:1.8 mM
In vitro	Chloroquinoxaline sulfonamide-induced protein-DNA cross-links and topoisomerase II-DNA cross-links in CV-1 cells [1]. Chloroquinoxaline sulfonamide inhibits the proliferation of mouse B16 melanoma cells, but only when a relatively high drug concentration (1 mM) is used [2]. The IC50 value of chloroquinoxaline sulfonamide on CV-1 cells was 1.8 mM using MTT cytotoxicity assay.
Synonyms	NSC-339004, Chloroquinoxaline

Chemical Properties

Molecular Weight	334.78
Formula	C₁₄H₁₁ClN₄O₂S
Cas No.	97919-22-7
Smiles	Nc1ccc(cc1)S(=O)(=O)Nc1cnc2c(Cl)cccc2n1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (298.70 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9870 mL	14.9352 mL	29.8704 mL	149.3518 mL
5 mM	0.5974 mL	2.9870 mL	5.9741 mL	29.8704 mL
10 mM	0.2987 mL	1.4935 mL	2.9870 mL	14.9352 mL
20 mM	0.1494 mL	0.7468 mL	1.4935 mL	7.4676 mL
50 mM	0.0597 mL	0.2987 mL	0.5974 mL	2.9870 mL
100 mM	0.0299 mL	0.1494 mL	0.2987 mL	1.4935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc