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Chloroquinoxaline sulfonamide

Name: Chloroquinoxaline sulfonamide
Brand: TargetMol
SKU: T14953
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14953Cas No. 97919-22-7

Alias NSC-339004, Chloroquinoxaline

Chloroquinoxaline sulfonamide (Chloroquinoxaline) is a topoisomerase II alpha/beta toxin with antitumor activity and immunosuppressive properties that inhibits the proliferation of B16 melanoma cells in mice, and can be used to study metastatic colorectal cancer. It can be used to study metastatic colorectal cancer.

Chloroquinoxaline sulfonamide

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Purity: 99.89%

Catalog No. T14953Alias NSC-339004, ChloroquinoxalineCas No. 97919-22-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	In Stock	In Stock
5 mg	$128	In Stock	In Stock
10 mg	$187	In Stock	In Stock
25 mg	$312	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$678	In Stock	In Stock
500 mg	$1,430	-	In Stock
1 mL x 10 mM (in DMSO)	$138	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:Yellow

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COA LCMS

Product Introduction

Bioactivity

Description	Chloroquinoxaline sulfonamide (Chloroquinoxaline) is a topoisomerase II alpha/beta toxin with antitumor activity and immunosuppressive properties that inhibits the proliferation of B16 melanoma cells in mice, and can be used to study metastatic colorectal cancer. It can be used to study metastatic colorectal cancer.
Targets&IC50	CV-1 cells:1.8 mM
In vitro	Chloroquinoxaline sulfonamide-induced protein-DNA cross-links and topoisomerase II-DNA cross-links in CV-1 cells [1]. Chloroquinoxaline sulfonamide inhibits the proliferation of mouse B16 melanoma cells, but only when a relatively high drug concentration (1 mM) is used [2]. The IC50 value of chloroquinoxaline sulfonamide on CV-1 cells was 1.8 mM using MTT cytotoxicity assay.
Synonyms	NSC-339004, Chloroquinoxaline

Chemical Properties

Molecular Weight	334.78
Formula	C₁₄H₁₁ClN₄O₂S
Cas No.	97919-22-7
Smiles	Nc1ccc(cc1)S(=O)(=O)Nc1cnc2c(Cl)cccc2n1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (298.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9870 mL	14.9352 mL	29.8704 mL	149.3518 mL
5 mM	0.5974 mL	2.9870 mL	5.9741 mL	29.8704 mL
10 mM	0.2987 mL	1.4935 mL	2.9870 mL	14.9352 mL
20 mM	0.1494 mL	0.7468 mL	1.4935 mL	7.4676 mL
50 mM	0.0597 mL	0.2987 mL	0.5974 mL	2.9870 mL
100 mM	0.0299 mL	0.1494 mL	0.2987 mL	1.4935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc