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GNE-2256
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Catalog No. T73372Cas No. 2102170-43-2
Alias GNE-2256, GNE2256, GNE 2256
GNE-2256 (molecule 19) is an orally active inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) with a binding affinity of 1.4 nM and an IL-6 IC50 value of 190 nM, making it a valuable research compound for studying inflammatory signaling cascades, innate immune responses, and cytokine-driven pathological processes.
GNE-2256
😃Good
Purity: 99.95%
Catalog No. T73372Alias GNE-2256, GNE2256, GNE 2256Cas No. 2102170-43-2
GNE-2256 (molecule 19) is an orally active inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) with a binding affinity of 1.4 nM and an IL-6 IC50 value of 190 nM, making it a valuable research compound for studying inflammatory signaling cascades, innate immune responses, and cytokine-driven pathological processes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $588 | - | In Stock | |
| 5 mg | $1,280 | - | In Stock | |
| 10 mg | $1,730 | - | In Stock | |
| 25 mg | $2,570 | - | In Stock | |
| 50 mg | $3,380 | - | In Stock | |
| 100 mg | $4,600 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.95%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GNE-2256 (molecule 19) is an orally active inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) with a binding affinity of 1.4 nM and an IL-6 IC50 value of 190 nM, making it a valuable research compound for studying inflammatory signaling cascades, innate immune responses, and cytokine-driven pathological processes. |
| Targets&IC50 | IL-6:190 nM, IRAK4:1.4 nM |
| In vivo | Method: GNE-2256 was administered at 3 mg/kg in an R848-induced mouse Parkinson’s disease model. Result: GNE-2256 inhibited IL-6, TNF-α, and IFN-α secretion in vivo[1]. |
| Synonyms | GNE-2256, GNE2256, GNE 2256 |
| Molecular Weight | 482.51 |
| Formula | C24H27FN6O4 |
| Cas No. | 2102170-43-2 |
| Smiles | N(C(=O)C1=C2N(N=C1)C=CC=N2)C3=C(C=C4C(=C3)CN(C[C@H](C(C)(C)O)F)C4=O)N5CCOCC5 |
| Color | White |
| Appearance | Solid |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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