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Riboflavin Tetrabutyrate

Name: Riboflavin Tetrabutyrate
Brand: TargetMol
SKU: T16747
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16747Cas No. 752-56-7

Riboflavin Tetrabutyrate, a lipophilic flavin derivative, possesses antioxidative and lipid peroxide-removing activities.

Riboflavin Tetrabutyrate

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Purity: 99.10%

Catalog No. T16747Cas No. 752-56-7

Riboflavin Tetrabutyrate, a lipophilic flavin derivative, possesses antioxidative and lipid peroxide-removing activities.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$33	-	In Stock
1 mL x 10 mM (in DMSO)	$50	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.10%

Appearance:Solid

Color:Orange

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Riboflavin Tetrabutyrate, a lipophilic flavin derivative, possesses antioxidative and lipid peroxide-removing activities.
In vitro	Riboflavin Tetrabutyrate effectively suppresses NADPH-coupled and ascorbate-induced microsomal lipid peroxidation, also inhibiting oxygen uptake during such peroxidation. It appears to exert its antioxidative effects during or after the enzymic oxidation-reduction process, specifically after the abstraction of a hydrogen atom as a free radical from the active methylene group in polyunsaturated fatty acids[1].
In vivo	Riboflavin Tetrabutyrate may enhance lipid metabolism in patients with atherosclerosis, diabetes, and fatty liver by inhibiting lipid peroxidation, resulting in decreased serum lipid levels. Prolonged administration increases hepatic 3-ketoacyl-CoA thiolase activity, promoting beta-oxidation of fatty acids in the liver, without affecting renal 3-ketoacyl-CoA thiolase, hepatic or renal acyl-CoA synthetase, and acyl-CoA dehydrogenase activities [1][2].

Chemical Properties

Molecular Weight	656.72
Formula	C₃₃H₄₄N₄O₁₀
Cas No.	752-56-7
Smiles	CCCC(=O)OC[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)[C@H](Cn1c2cc(C)c(C)cc2nc2c(O)nc(=O)nc12)OC(=O)CCC
Relative Density.	1.29g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (152.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5227 mL	7.6136 mL	15.2272 mL	76.1359 mL
5 mM	0.3045 mL	1.5227 mL	3.0454 mL	15.2272 mL
10 mM	0.1523 mL	0.7614 mL	1.5227 mL	7.6136 mL
20 mM	0.0761 mL	0.3807 mL	0.7614 mL	3.8068 mL
50 mM	0.0305 mL	0.1523 mL	0.3045 mL	1.5227 mL
100 mM	0.0152 mL	0.0761 mL	0.1523 mL	0.7614 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc