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BAY32-5915

Name: BAY32-5915
Brand: TargetMol
SKU: T20770
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20770Cas No. 1571-30-8

Alias BAY-32-5915, BAY 32-5915, BAY 32 5915

BAY32-5915 is a selective inhibitor of IKKalpha.

BAY32-5915

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Purity: 97%

Catalog No. T20770Alias BAY-32-5915, BAY 32-5915, BAY 32 5915Cas No. 1571-30-8

BAY32-5915 is a selective inhibitor of IKKalpha.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$39	In Stock	In Stock
500 mg	$84	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

BAY32-5915 AI Summary

BAY32-5915 is a broad-spectrum inhibitor exhibiting bioactivities across various biological assays. It significantly inhibits human JMJD2E, MLL CXXC domain-DNA interaction, Giardia lamblia fructose-1,6-bisphosphate aldolase, Bacillus subtilis Sfp phosphopantetheinyl transferase, and BAZ2B, with potencies ranging from 366.3 nM to 350,000 nM. The compound shows diverse inhibitory effects on several human recombinant matrix metalloproteinases (MMPs), lipoxygenase, and mushroom tyrosinase, as well as notable inhibition of anthrax lethal factor and bacterial metallo-beta-lactamases (NDM-1, VIM-1, IMP-1). Additionally, it induces DNA re-replication in SW480 colon adenocarcinoma cells and activates integrin pathways beneficial for muscular dystrophy. BAY32-5915 has a LogD7.4 value of 3.3, suggesting favorable distribution in biological systems. It also inhibits Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase with an IC50 of 10,000 nM and exerts potent inhibition against bacterial enzymes, showing potential as an antibiotic and antiparasitic candidate. The compound exhibits inhibition of Clostridium botulinum BoNT/A1 and recombinant human quinolinic acid carboxylase enzyme, further illustrating its diverse inhibitory profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BAY32-5915 is a selective inhibitor of IKKalpha.
Targets&IC50	IKKα:60 nM
Synonyms	BAY-32-5915, BAY 32-5915, BAY 32 5915

Chemical Properties

Molecular Weight	189.17
Formula	C₁₀H₇NO₃
Cas No.	1571-30-8
Smiles	OC(=O)C1=NC2=C(O)C=CC=C2C=C1
Relative Density.	1.3175 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (290.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2863 mL	26.4313 mL	52.8625 mL	264.3125 mL
5 mM	1.0573 mL	5.2863 mL	10.5725 mL	52.8625 mL
10 mM	0.5286 mL	2.6431 mL	5.2863 mL	26.4313 mL
20 mM	0.2643 mL	1.3216 mL	2.6431 mL	13.2156 mL
50 mM	0.1057 mL	0.5286 mL	1.0573 mL	5.2863 mL
100 mM	0.0529 mL	0.2643 mL	0.5286 mL	2.6431 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc