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CaV1.3 antagonist-1

Name: CaV1.3 antagonist-1
Brand: TargetMol
SKU: T61026
Rating: 4.5 (1 reviews)

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Catalog No. T61026Cas No. 1391385-57-1

CaV1.3 antagonist-1 is a selective CaV1.3L-type calcium channel antagonist useful for researching neurological disorders and cardiovascular diseases.

CaV1.3 antagonist-1

😃Good

Catalog No. T61026Cas No. 1391385-57-1

CaV1.3 antagonist-1 is a selective CaV1.3L-type calcium channel antagonist useful for researching neurological disorders and cardiovascular diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$977	6-8 weeks	6-8 weeks
50 mg	$1,270	6-8 weeks	6-8 weeks
100 mg	$1,990	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	CaV1.3 antagonist-1 is a selective CaV1.3L-type calcium channel antagonist useful for researching neurological disorders and cardiovascular diseases.
Targets&IC50	Cav 1.3:1.7 μM
In vitro	CaV1.3 antagonist-1 is a CAV1.3L calcium channel antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 (5μM) inhibited the CaV1.3 and CaV1.2 channel currents in HEK293 cells by 31.2% and 4.4%, respectively. [1]

Chemical Properties

Molecular Weight	334.8
Formula	C₁₇H₁₉ClN₂O₃
Cas No.	1391385-57-1
Smiles	O=C1N(C(=O)CC(=O)N1C2CCCC2)CCC=3C=CC=C(Cl)C3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (238.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9869 mL	14.9343 mL	29.8686 mL	149.3429 mL
5 mM	0.5974 mL	2.9869 mL	5.9737 mL	29.8686 mL
10 mM	0.2987 mL	1.4934 mL	2.9869 mL	14.9343 mL
20 mM	0.1493 mL	0.7467 mL	1.4934 mL	7.4671 mL
50 mM	0.0597 mL	0.2987 mL	0.5974 mL	2.9869 mL
100 mM	0.0299 mL	0.1493 mL	0.2987 mL	1.4934 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc