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CaV1.3 antagonist-1

Name: CaV1.3 antagonist-1
Brand: TargetMol
SKU: T61026
Rating: 4.5 (1 reviews)

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Catalog No. T61026Cas No. 1391385-57-1

CaV1.3 antagonist-1 is a selective CaV1.3L-type calcium channel antagonist useful for researching neurological disorders and cardiovascular diseases.

CaV1.3 antagonist-1

😃Good

Catalog No. T61026Cas No. 1391385-57-1

CaV1.3 antagonist-1 is a selective CaV1.3L-type calcium channel antagonist useful for researching neurological disorders and cardiovascular diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$977	6-8 weeks	6-8 weeks
50 mg	$1,270	6-8 weeks	6-8 weeks
100 mg	$1,990	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	CaV1.3 antagonist-1 is a selective CaV1.3L-type calcium channel antagonist useful for researching neurological disorders and cardiovascular diseases.
Targets&IC50	Cav 1.3:1.7 μM
In vitro	CaV1.3 antagonist-1 is a CAV1.3L calcium channel antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 (5μM) inhibited the CaV1.3 and CaV1.2 channel currents in HEK293 cells by 31.2% and 4.4%, respectively. [1]

Chemical Properties

Molecular Weight	334.8
Formula	C₁₇H₁₉ClN₂O₃
Cas No.	1391385-57-1
Smiles	O=C1N(C(=O)CC(=O)N1C2CCCC2)CCC=3C=CC=C(Cl)C3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (238.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9869 mL	14.9343 mL	29.8686 mL	149.3429 mL
5 mM	0.5974 mL	2.9869 mL	5.9737 mL	29.8686 mL
10 mM	0.2987 mL	1.4934 mL	2.9869 mL	14.9343 mL
20 mM	0.1493 mL	0.7467 mL	1.4934 mL	7.4671 mL
50 mM	0.0597 mL	0.2987 mL	0.5974 mL	2.9869 mL
100 mM	0.0299 mL	0.1493 mL	0.2987 mL	1.4934 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc