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DuP 105

Name: DuP 105
Brand: TargetMol
SKU: T11123
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Synonyms:

Catalog No. T11123 Copy Product Info

Purity: 99.82%

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DuP 105 is an oxazolidinone compound and a bacterial protein synthesis inhibitor with oral activity and selective antibacterial activity against Gram-positive bacteria. It can be used to study infections caused by susceptible Gram-positive bacteria such as staphylococci and streptococci, and has shown protective effects in animal models.

Cas No. 96800-41-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$56	In Stock	In Stock
5 mg	$139	In Stock	In Stock
10 mg	$222	In Stock	In Stock
25 mg	$446	In Stock	In Stock
50 mg	$716	In Stock	In Stock
100 mg	$1,130	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.82%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	DuP 105 is an oxazolidinone compound and a bacterial protein synthesis inhibitor with oral activity and selective antibacterial activity against Gram-positive bacteria. It can be used to study infections caused by susceptible Gram-positive bacteria such as staphylococci and streptococci, and has shown protective effects in animal models.
In vitro	Methods: DuP 105 (4–16 μg/mL) was used to treat various clinically isolated strains, including Staphylococcus species (S. aureus, S. epidermidis, S. haemolyticus, S. hominis), Streptococcus species (Lancefield groups A, B, D, including Enterococcus faecalis), and Bacteroides fragilis, to assess growth inhibition. Results: DuP 105 inhibited the growth of all tested strains.[1]
In vivo	Methods: To assess in vivo antibacterial activity, CF-1 mice infected with Staphylococcus aureus 1A were administered DuP 105 (100 mg/kg, subcutaneous injection or oral, twice daily for 4 days), and bacterial load in the kidneys was determined. Results: DuP 105 reduced Staphylococcus aureus 1A load in mouse kidneys. [1]

Chemical Properties

Molecular Weight	296.34
Formula	C₁₃H₁₆N₂O₄S
Cas No.	96800-41-8
Smiles	O=C1N(C[C@H](CNC(C)=O)O1)C2=CC=C(S(C)=O)C=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (151.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3745 mL	16.8725 mL	33.7450 mL	168.7251 mL
5 mM	0.6749 mL	3.3745 mL	6.7490 mL	33.7450 mL
10 mM	0.3375 mL	1.6873 mL	3.3745 mL	16.8725 mL
20 mM	0.1687 mL	0.8436 mL	1.6873 mL	8.4363 mL
50 mM	0.0675 mL	0.3375 mL	0.6749 mL	3.3745 mL
100 mM	0.0337 mL	0.1687 mL	0.3375 mL	1.6873 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc