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DuP 105

🥰Excellent
Catalog No. T11123Cas No. 96800-41-8

DuP 105 is an oral oxazolidinone, a novel synthetic antimicrobial compound effective against gram-positive bacteria.

DuP 105

DuP 105

🥰Excellent
Purity: 99.82%
Catalog No. T11123Cas No. 96800-41-8
DuP 105 is an oral oxazolidinone, a novel synthetic antimicrobial compound effective against gram-positive bacteria.
Pack SizePriceAvailabilityQuantity
1 mg$56In Stock
5 mg$139In Stock
10 mg$222In Stock
25 mg$446In Stock
50 mg$716In Stock
100 mg$1,130In Stock
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Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.82%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
DuP 105 is an oral oxazolidinone, a novel synthetic antimicrobial compound effective against gram-positive bacteria.
In vitro
DuP 105 MICs for 50% of the 216 gram-positive isolates tested (MIC50s) range from 4.0 to 16 μg/mL.DuP 105 shows inhibitory activities against staphylococcal isolates and B. fragilis isolates with MIC90s of 4 to 16 μg/mL and 16 μg/mL.
In vivo
Administered orally or parenterally, DuP 105 effectively safeguards mice against staphylococcal and streptococcal infections, displaying 50% efficacy at doses ranging from 9 to 23 mg/kg.
Chemical Properties
Molecular Weight296.34
FormulaC13H16N2O4S
Cas No.96800-41-8
SmilesO=C1N(C[C@H](CNC(C)=O)O1)C2=CC=C(S(C)=O)C=C2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (151.85 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3745 mL16.8725 mL33.7450 mL168.7251 mL
5 mM0.6749 mL3.3745 mL6.7490 mL33.7450 mL
10 mM0.3375 mL1.6873 mL3.3745 mL16.8725 mL
20 mM0.1687 mL0.8436 mL1.6873 mL8.4363 mL
50 mM0.0675 mL0.3375 mL0.6749 mL3.3745 mL
100 mM0.0337 mL0.1687 mL0.3375 mL1.6873 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

DuP-105DuP105DuP 105
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