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Upamostat

Name: Upamostat
Brand: TargetMol
SKU: T13257
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13257Cas No. 590368-25-5

Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.

Upamostat

🥰Excellent

Purity: 99.41%

Catalog No. T13257Cas No. 590368-25-5

Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.

Pack Size	Price	Availability
1 mg	$58	In Stock
2 mg	$86	In Stock
5 mg	$148	In Stock
10 mg	$238	In Stock
25 mg	$398	In Stock
50 mg	$567	In Stock
100 mg	$768	In Stock
1 mL x 10 mM (in DMSO)	$166	In Stock

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Batch Information

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Purity:99.41%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.

In vitro

Upamostat is an inhibitor of urokinase plasminogen activator (uPA). Upamostat is the oral prodrug of the active metabolite WX-UK1, a novel inhibitor of uPA [1]. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, and plays a major role in tumor invasion and metastasis. Upamostat is the orally available amidoxime- (i.e. hydroxyamidine-) prodrug of the pharmacologically active form, WX-UK1 [2].

Chemical Properties

Molecular Weight	629.81
Formula	C₃₂H₄₇N₅O₆S
Cas No.	590368-25-5
Smiles	CCOC(=O)N1CCN(CC1)C(=O)[C@H](Cc1cccc(c1)C(=N)NO)NS(=O)(=O)c1c(cc(cc1C(C)C)C(C)C)C(C)C
Relative Density.	1.25 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (396.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5878 mL	7.9389 mL	15.8778 mL	79.3890 mL
5 mM	0.3176 mL	1.5878 mL	3.1756 mL	15.8778 mL
10 mM	0.1588 mL	0.7939 mL	1.5878 mL	7.9389 mL
20 mM	0.0794 mL	0.3969 mL	0.7939 mL	3.9695 mL
50 mM	0.0318 mL	0.1588 mL	0.3176 mL	1.5878 mL
100 mM	0.0159 mL	0.0794 mL	0.1588 mL	0.7939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc