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Aplindore Fumarate

Name: Aplindore Fumarate
Brand: TargetMol
SKU: T30098
Price: 176 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T30098Cas No. 189681-71-8

Alias DAB-452 Fumarate, DAB452 Fumarate

Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors, and low affinity for dopamine D4, 5-hydroxytryptophan (5-HT2), and α1-adrenergic receptors.Aplindore Fumarate is used in the study of Parkinson's disease and schizophrenia. Fumarate can be used to study Parkinson's and schizophrenia.

Aplindore Fumarate

🥰Excellent

Catalog No. T30098Alias DAB-452 Fumarate, DAB452 FumarateCas No. 189681-71-8

Pack Size	Price	Availability
1 mg	$176	In Stock
5 mg	$440	In Stock
10 mg	$592	In Stock
25 mg	$918	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:>99.99%

ee:98.52%

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COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors, and low affinity for dopamine D4, 5-hydroxytryptophan (5-HT2), and α1-adrenergic receptors.Aplindore Fumarate is used in the study of Parkinson's disease and schizophrenia. Fumarate can be used to study Parkinson's and schizophrenia.
Synonyms	DAB-452 Fumarate, DAB452 Fumarate

Chemical Properties

Molecular Weight	426.42
Formula	C₂₂H₂₂N₂O₇
Cas No.	189681-71-8
Smiles	C(=C/C(O)=O)\C(O)=O.C(NCC1=CC=CC=C1)[C@@H]2OC=3C4=C(C=CC3OC2)NC(=O)C4
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (117.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3451 mL	11.7255 mL	23.4511 mL	117.2553 mL
5 mM	0.4690 mL	2.3451 mL	4.6902 mL	23.4511 mL
10 mM	0.2345 mL	1.1726 mL	2.3451 mL	11.7255 mL
20 mM	0.1173 mL	0.5863 mL	1.1726 mL	5.8628 mL
50 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3451 mL
100 mM	0.0235 mL	0.1173 mL	0.2345 mL	1.1726 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc