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GT 949

Name: GT 949
Brand: TargetMol
SKU: T15446
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15446Cas No. 460330-27-2

GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) with an EC50 of 0.26 nM.

GT 949

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Purity: 99.95%

Catalog No. T15446Cas No. 460330-27-2

GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) with an EC50 of 0.26 nM.

Pack Size	Price	Availability
10 mg	$48	In Stock
25 mg	$96	In Stock
50 mg	$173	In Stock
100 mg	$260	In Stock
200 mg	$369	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock

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Purity:99.95%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) with an EC50 of 0.26 nM.
Targets&IC50	EAAT2:(EC50)0.26±0.03 nM
In vitro	GT 949 displays selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3. GT 949 improves glutamate transport (EC50 = 0.26 nM) and increases glutamate transport in a non-competitive manner with an increase in Vmax of about 47% in EAAT2-transfected cells[1].

Chemical Properties

Molecular Weight	527.66
Formula	C₃₀H₃₇N₇O₂
Cas No.	460330-27-2
Smiles	COc1ccc2[nH]c(=O)c(cc2c1)C(N1CCN(CC1)C1CCCCC1)c1nnnn1CCc1ccccc1
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (104.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8952 mL	9.4758 mL	18.9516 mL	94.7580 mL
5 mM	0.3790 mL	1.8952 mL	3.7903 mL	18.9516 mL
10 mM	0.1895 mL	0.9476 mL	1.8952 mL	9.4758 mL
20 mM	0.0948 mL	0.4738 mL	0.9476 mL	4.7379 mL
50 mM	0.0379 mL	0.1895 mL	0.3790 mL	1.8952 mL
100 mM	0.0190 mL	0.0948 mL	0.1895 mL	0.9476 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc