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PEO-IAA (Synonyms: 2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid)

Name: PEO-IAA
Brand: TargetMol
SKU: T4603
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T4603 Copy Product Info

Purity: 99.61%

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PEO-IAA (2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid) is a novel potent auxin antagonist.

PEO-IAA

Copy Product Info

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Catalog No. T4603

Synonyms 2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid

PEO-IAA (2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid) is a novel potent auxin antagonist.

Cas No. 6266-66-6

Pack Size	Price	USA Stock	Global Stock
10 mg	$36	In Stock	In Stock
25 mg	$54	In Stock	In Stock
50 mg	$74	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.61%

Resource Download

COA HNMR LCMS

Product Introduction

PEO-IAA AI Summary

PEO-IAA exhibits a wide range of bioactivities as an inhibitor or activator in several biological assays. Notably, it shows potency in inhibiting the Menin-MLL interaction in MLL-related leukemias, modulating miRNAs, activating miR-21, and inhibiting Tau fibril formation. Additionally, this compound displays actions as an activator of the human muscle isoform 2 pyruvate kinase and as a modulator of lipid storage. It also inhibits Schistosoma Mansoni peroxiredoxins, influenza NS1 protein function, B-cell receptor signaling, the Rango (Ran-regulated importin-beta cargo) - Importin beta complex, the binding or entry of Lassa Virus into cells, and MBNL1-poly(CUG) RNA binding. Furthermore, PEO-IAA acts as a delayed death inhibitor of the malarial parasite plastid and functions either as an inhibitor or activator of firefly luciferase. The potency of the compound across these varied assays ranges from 2238.7 nM to 100000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PEO-IAA (2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid) is a novel potent auxin antagonist.
Synonyms	2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid

Chemical Properties

Molecular Weight	293.32
Formula	C₁₈H₁₅NO₃
Cas No.	6266-66-6
Smiles	OC(=O)C(CC(=O)C1=CC=CC=C1)C1=CNC2=CC=CC=C12
Relative Density.	1.318 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (835.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4092 mL	17.0462 mL	34.0925 mL	170.4623 mL
5 mM	0.6818 mL	3.4092 mL	6.8185 mL	34.0925 mL
10 mM	0.3409 mL	1.7046 mL	3.4092 mL	17.0462 mL
20 mM	0.1705 mL	0.8523 mL	1.7046 mL	8.5231 mL
50 mM	0.0682 mL	0.3409 mL	0.6818 mL	3.4092 mL
100 mM	0.0341 mL	0.1705 mL	0.3409 mL	1.7046 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc