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Isoanhydroicaritin

Name: Isoanhydroicaritin
Brand: TargetMol
SKU: TN1771
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1771Cas No. 28610-30-2

Isoanhydroicaritin is a naturally occurring flavonoid that inhibits physiological melanin synthesis and recovery and inhibits mushroom tyrosinase.

Isoanhydroicaritin

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Purity: 99.89%

Catalog No. TN1771Cas No. 28610-30-2

Isoanhydroicaritin is a naturally occurring flavonoid that inhibits physiological melanin synthesis and recovery and inhibits mushroom tyrosinase.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$238	-	In Stock
10 mg	$357	-	In Stock
25 mg	$593	-	In Stock
50 mg	$845	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Isoanhydroicaritin is a naturally occurring flavonoid that inhibits physiological melanin synthesis and recovery and inhibits mushroom tyrosinase.
Targets&IC50	Mushroom Tyrosinase:0.7 μM
In vitro	Isoanhydroicaritin exhibits strong inhibitory activity against mushroom tyrosinase, with an IC₅₀ of 0.7 μM.[1]
In vivo	In zebrafish, Isoanhydroicaritin at 80 and 160 μM inhibits physiological melanin biosynthesis by approximately 30%. [1] In a zebrafish depigmentation model, Isoanhydroicaritin at the same doses suppresses pigment regeneration by 33.0% and 34.4%, respectively.[1]

Chemical Properties

Molecular Weight	368.38
Formula	C₂₁H₂₀O₆
Cas No.	28610-30-2
Smiles	O=C1C(O)=C(OC=2C1=C(O)C=C(OC)C2CC=C(C)C)C=3C=CC(O)=CC3
Relative Density.	1.359 g/cm3 at 20℃

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (108.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7146 mL	13.5729 mL	27.1459 mL	135.7294 mL
5 mM	0.5429 mL	2.7146 mL	5.4292 mL	27.1459 mL
10 mM	0.2715 mL	1.3573 mL	2.7146 mL	13.5729 mL
20 mM	0.1357 mL	0.6786 mL	1.3573 mL	6.7865 mL
50 mM	0.0543 mL	0.2715 mL	0.5429 mL	2.7146 mL
100 mM	0.0271 mL	0.1357 mL	0.2715 mL	1.3573 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc