ATP2A2 Protein, Human, Recombinant (C-His)

Name: ATP2A2 Protein, Human, Recombinant (C-His)
Brand: TargetMol
SKU: TMPH-03766
Rating: 4.5 (1 reviews)

(Synonyms: SR Ca(2+)-ATPase 2, SERCA2, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Calcium pump 2, ATP2B, ATP2A2) Copy Product Info

Synonyms: SR Ca(2+)-ATPase 2, SERCA2, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Calcium pump 2, ATP2B, ATP2A2

Catalog No. TMPH-03766 Copy Product Info

Purity: 95%

ATP2A2 Protein, Human, Recombinant (C-His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 55.2 kDa and the accession number is P16615.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$79	12 days	12 days
10 µg	$128	12 days	12 days
20 µg	$210	12 days	12 days
50 µg	$315	12 days	12 days
100 µg	$429	12 days	12 days
200 µg	$663	12 days	12 days
500 µg	$1,180	12 days	12 days
1 mg	$1,850	12 days	12 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:95%

Appearance:Lyophilized powder

Color:White

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COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	ATP2A2 Protein, Human, Recombinant (C-His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 55.2 kDa and the accession number is P16615.
Expression System	E. coli
Protein Purity	> 95% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Synonyms	SR Ca(2+)-ATPase 2, SERCA2, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Calcium pump 2, ATP2B, ATP2A2
Research Background	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes.; Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation.