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Exo1

Name: Exo1
Brand: TargetMol
SKU: T4609
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4609Cas No. 75541-83-2

Exo1 is an inhibitor of the exocytic pathway

Exo1

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Purity: 98.75%

Catalog No. T4609Cas No. 75541-83-2

Exo1 is an inhibitor of the exocytic pathway

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$38	In Stock	In Stock
25 mg	$78	In Stock	In Stock
50 mg	$139	In Stock	In Stock
100 mg	$197	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.75%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Exo1 is an inhibitor of the exocytic pathway

In vitro

Exo1 functions as a modifier of Golgi ARF1 GTPase activity, offering a unique approach to modulate Golgi function. Unlike agents like BFA, Exo1 targets a specific subset of membrane processes associated with the Golgi, presumably interacting with a different protein target, which could lead to distinct side effects. It disrupts vesicular traffic between the Endoplasmic Reticulum (ER) and the Golgi apparatus by altering Golgi structures, effectively inhibiting exocytosis with an IC50 value of approximately 20 μM. Furthermore, Exo1 impedes the acquisition of endoglycosidase H resistance in newly synthesized proteins, including VSVGts-GFP, transferrin, and MHC class I[1], indicative of its role in the intricate regulation of protein trafficking and modification.

Chemical Properties

Molecular Weight	273.26
Formula	C₁₅H₁₂FNO₃
Cas No.	75541-83-2
Smiles	COC(=O)c1ccccc1NC(=O)c1ccc(F)cc1
Relative Density.	1.298 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (82.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (7.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6595 mL	18.2976 mL	36.5952 mL	182.9759 mL
5 mM	0.7319 mL	3.6595 mL	7.3190 mL	36.5952 mL
10 mM	0.3660 mL	1.8298 mL	3.6595 mL	18.2976 mL
20 mM	0.1830 mL	0.9149 mL	1.8298 mL	9.1488 mL
50 mM	0.0732 mL	0.3660 mL	0.7319 mL	3.6595 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc