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Pan-RAS-IN-2
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Catalog No. T88116Cas No. 3034673-92-9
Pan-RAS-IN-2 (compound 6A) is an orally active molecular glue that targets RAS by inducing ternary complex formation with cyclophilin A (CYPA) and RAS in the ON state, leading to potent inhibition of downstream RAF binding and pERK signaling with an IC50 of 0.3 nM in AsPC-1 cells, Pan-RAS-IN-2 demonstrates strong antiproliferative effects in RAS-mutant cancer cell lines, supporting research into targeted therapies for colorectal and pancreatic cancers.
Pan-RAS-IN-2
😃Good
Purity: 99.81%
Catalog No. T88116Cas No. 3034673-92-9
Pan-RAS-IN-2 (compound 6A) is an orally active molecular glue that targets RAS by inducing ternary complex formation with cyclophilin A (CYPA) and RAS in the ON state, leading to potent inhibition of downstream RAF binding and pERK signaling with an IC50 of 0.3 nM in AsPC-1 cells, Pan-RAS-IN-2 demonstrates strong antiproliferative effects in RAS-mutant cancer cell lines, supporting research into targeted therapies for colorectal and pancreatic cancers.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $158 | - | In Stock | |
| 5 mg | $396 | - | In Stock | |
| 10 mg | $635 | - | In Stock | |
| 25 mg | $1,280 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $585 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.81%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pan-RAS-IN-2 (compound 6A) is an orally active molecular glue that targets RAS by inducing ternary complex formation with cyclophilin A (CYPA) and RAS in the ON state, leading to potent inhibition of downstream RAF binding and pERK signaling with an IC50 of 0.3 nM in AsPC-1 cells, Pan-RAS-IN-2 demonstrates strong antiproliferative effects in RAS-mutant cancer cell lines, supporting research into targeted therapies for colorectal and pancreatic cancers. |
| In vitro | In AsPC-1 pancreatic cancer cells, Pan-RAS-IN-2 potently inhibited pERK levels with an IC50 of 0.3 nM. The compound demonstrated significant antiproliferative activity across a broad spectrum of RAS-mutant cancer cell lines, including those harboring KRAS G12D, G12V, and G12C mutations [1]. |
| In vivo | Pan-RAS-IN-2 exhibited robust antitumor efficacy in mouse xenograft models of RAS-driven cancers, such as colorectal and pancreatic cancer. Oral administration of Pan-RAS-IN-2 resulted in the significant inhibition of tumor growth [1]. |
| Molecular Weight | 837.08 |
| Formula | C46H60N8O5S |
| Cas No. | 3034673-92-9 |
| Smiles | O=C1OCC(C)(C)CC=2C3=CC(=CC=C3N(C2C=4C=C(C=NC4C(OC)C)N5CCN(C)CC5)CC)C=6N=C(SC6)CC(NC(=O)C7C(C)C7C)C(=O)N8NC1C9CC8C9 |
| Color | White |
| Appearance | Solid |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (95.57 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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