NRA-0160

Name: NRA-0160
Brand: TargetMol
SKU: T12252
Rating: 4.5 (1 reviews)

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Catalog No. T12252Cas No. 204718-47-8

NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)

NRA-0160

😃Good

Catalog No. T12252Cas No. 204718-47-8

NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
Targets&IC50	α1-adrenoceptor (rat):237 nM (ki), D4 receptor:0.48 nM (ki), 5-HT2A receptor:180 nM (Ki, in rat), D3 receptor:39 nM (ki)
In vivo	NRA0160 dose-dependently and significantly reverses the effects of MAP on both A9 and Al0 dopamine neurons.?NRA0160 is slightly more potent in reversiig the effects of MAP on A10 (ED50 = 1.0 mg/kg) than on A9 dopamine neurons (ED50 = 1.3 mg/kg).?NRA0160 reverses the effect of AP0 on both A9 and A10 dopamine neurons.?ED50 values for the effects of NRA0160 on APO-induced inhibition of A9 and A10 dopamine neurons are 1.3 mg/kg and 0.5 mg/kg, respectively[2].

Chemical Properties

Molecular Weight	439.52
Formula	C₂₄H₂₃F₂N₃OS
Cas No.	204718-47-8
Relative Density.	1.297 g/cm3 (Predicted)

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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