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SW2_110A

Name: SW2_110A
Brand: TargetMol
SKU: T36798
Price: 110 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36798Cas No. 2579696-95-8

SW2_110A is a cell-permeable, selective chromosome group 8 chromosome domain (CBX8 ChD) inhibitor with a Kd of 800 nM. In vitro, SW2_110A is 5-fold more selective for CBX8 ChD than all other CBX enantiomers.

SW2_110A

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Catalog No. T36798Cas No. 2579696-95-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$110	-	In Stock
5 mg	$289	-	In Stock
25 mg	$788	-	In Stock
50 mg	$1,120	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	SW2_110A is a cell-permeable, selective chromosome group 8 chromosome domain (CBX8 ChD) inhibitor with a Kd of 800 nM. In vitro, SW2_110A is 5-fold more selective for CBX8 ChD than all other CBX enantiomers.
Targets&IC50	CBX8 ChD:800 nM(Kd )
In vitro	SW2_110A (100 µM; 24h) explicitly inhibits the association of CBX8 with chromatin in cells and inhibits the proliferation of THP1 leukemia cells driven by the MLL-AF9 translocation (IC50 of 26 µM). In THP1 cells, SW2_110A (100 µM; 24h) treatment results in a significant decrease in the expression of MLL-AF9 target genes, including HOXA9.[1]

Chemical Properties

Molecular Weight	760.96
Formula	C₄₂H₆₀N₆O₇
Cas No.	2579696-95-8
Smiles	[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC#C)=O)CO)=O)CCCCN(CC)CC)=O)[C@@H](CC)C)=O)(NC(=O)C1=CC=C(OC2=CC=CC=C2)C=C1)[C@H]3CCCC3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (147.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (5.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3141 mL	6.5706 mL	13.1413 mL	65.7065 mL
5 mM	0.2628 mL	1.3141 mL	2.6283 mL	13.1413 mL
10 mM	0.1314 mL	0.6571 mL	1.3141 mL	6.5706 mL
20 mM	0.0657 mL	0.3285 mL	0.6571 mL	3.2853 mL
50 mM	0.0263 mL	0.1314 mL	0.2628 mL	1.3141 mL
100 mM	0.0131 mL	0.0657 mL	0.1314 mL	0.6571 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc