store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SW2_110A is a cell-permeable, selective chromosome group 8 chromosome domain (CBX8 ChD) inhibitor with a Kd of 800 nM. In vitro, SW2_110A is 5-fold more selective for CBX8 ChD than all other CBX enantiomers.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 110.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 478.00 | |
25 mg | In stock | $ 788.00 | |
50 mg | Inquiry | $ 1,120.00 |
Description | SW2_110A is a cell-permeable, selective chromosome group 8 chromosome domain (CBX8 ChD) inhibitor with a Kd of 800 nM. In vitro, SW2_110A is 5-fold more selective for CBX8 ChD than all other CBX enantiomers. |
Targets&IC50 | CBX8 ChD:800 nM(Kd ) |
In vitro | SW2_110A (100 µM; 24h) explicitly inhibits the association of CBX8 with chromatin in cells and inhibits the proliferation of THP1 leukemia cells driven by the MLL-AF9 translocation (IC50 of 26 µM). In THP1 cells, SW2_110A (100 µM; 24h) treatment results in a significant decrease in the expression of MLL-AF9 target genes, including HOXA9.[1] |
Molecular Weight | 760.96 |
Formula | C42H60N6O7 |
CAS No. | 2579696-95-8 |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (147.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SW2_110A 2579696-95-8 Chromatin/Epigenetic Histone Methyltransferase SW-2_110A inhibitor inhibit