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Zoniporide

Name: Zoniporide
Brand: TargetMol
SKU: T21996L
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21996LCas No. 241800-98-6

Alias CP-597396, CP597396, CP 597396

Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits the uptake of 22Na+ by fibroblasts expressing human NHE-1 in a concentration-dependent manner, inhibits platelet swelling, and can be used in the study of cardiovascular diseases.

Zoniporide

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Purity: 99.74%

Catalog No. T21996LAlias CP-597396, CP597396, CP 597396Cas No. 241800-98-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
5 mg	$112	-	In Stock
10 mg	$179	-	In Stock
25 mg	$297	-	In Stock
50 mg	$455	-	In Stock
100 mg	$656	-	In Stock
200 mg	$919	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.74%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits the uptake of 22Na+ by fibroblasts expressing human NHE-1 in a concentration-dependent manner, inhibits platelet swelling, and can be used in the study of cardiovascular diseases.
In vivo	In rats, Zoniporide (1 mg/kg; i.v.) shows the AUC0-∞ = 0.07 μg h/mL, and t1/2 are 0.5 hours, respectively. [1] In open chest anesthetized rabbits, Zoniporide (0.25, 1, 4 mg/kg; i.v.) dose-dependently reduces infarct size with an ED50 = 0.45 mg/kg/h. Zoniporide exhibits moderate plasma protein binding with t1/2 of 1.5h in monkeys. [2]
Synonyms	CP-597396, CP597396, CP 597396

Chemical Properties

Molecular Weight	320.35
Formula	C₁₇H₁₆N₆O
Cas No.	241800-98-6
Smiles	O=C(NC(=N)N)C=1C=NN(C2=CC=CC3=NC=CC=C32)C1C4CC4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL(312.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1216 mL	15.6079 mL	31.2159 mL	156.0793 mL
5 mM	0.6243 mL	3.1216 mL	6.2432 mL	31.2159 mL
10 mM	0.3122 mL	1.5608 mL	3.1216 mL	15.6079 mL
20 mM	0.1561 mL	0.7804 mL	1.5608 mL	7.8040 mL
50 mM	0.0624 mL	0.3122 mL	0.6243 mL	3.1216 mL
100 mM	0.0312 mL	0.1561 mL	0.3122 mL	1.5608 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc