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L-AP4

Name: L-AP4
Brand: TargetMol
SKU: T15692
Rating: 4.5 (1 reviews)

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Catalog No. T15692Cas No. 23052-81-5

Alias L-APB, L-AP 4

L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).

L-AP4

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Catalog No. T15692Alias L-APB, L-AP 4Cas No. 23052-81-5

L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$198	35 days	35 days
5 mg	$352	35 days	35 days
10 mg	$589	35 days	35 days
50 mg	$2,490	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).
Targets&IC50	mGlu7:249 μM (EC50), mGlu6:1.0 μM (EC50), mGlu4:0.13 μM (EC50), mGlu8:0.29 μM (EC50)
In vivo	L-APB(5 to 30 μg; intrathecal injection) obviously enhances the paw withdrawal threshold in response to the application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration. Paw withdrawal threshold in response to the application of von Frey filaments before spinal nerve ligation is 22.6±2.4 g. The mechanical threshold decreases significantly (2.3±0.5 g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks [2].
Synonyms	L-APB, L-AP 4

Chemical Properties

Molecular Weight	183.1
Formula	C₄H₁₀NO₅P
Cas No.	23052-81-5
Smiles	C([C@@H](C(O)=O)N)CP(=O)(O)O
Relative Density.	1.628 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (273.07 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.4615 mL	27.3075 mL	54.6150 mL	273.0748 mL
5 mM	1.0923 mL	5.4615 mL	10.9230 mL	54.6150 mL
10 mM	0.5461 mL	2.7307 mL	5.4615 mL	27.3075 mL
20 mM	0.2731 mL	1.3654 mL	2.7307 mL	13.6537 mL
50 mM	0.1092 mL	0.5461 mL	1.0923 mL	5.4615 mL
100 mM	0.0546 mL	0.2731 mL	0.5461 mL	2.7307 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc