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CAY10730

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Catalog No. T36459Cas No. 2206677-06-5

CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia. In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 μM) has been used to detect hypoxia in A549 human lung carcinoma cells.

CAY10730

CAY10730

😃Good
Catalog No. T36459Cas No. 2206677-06-5
CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia. In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 μM) has been used to detect hypoxia in A549 human lung carcinoma cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$42935 days35 days
25 mg$1,73035 days35 days
50 mg$2,82035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia. In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 μM) has been used to detect hypoxia in A549 human lung carcinoma cells.
Chemical Properties
Molecular Weight481.46
FormulaC28H19NO7
Cas No.2206677-06-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 1 mg/mL (2.08 mM), Sonication is recommended.
DMSO: 20 mg/mL (41.54 mM), Sonication is recommended.
DMF: 20 mg/mL (41.54 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO/DMF
1mg5mg10mg50mg
1 mM2.0770 mL10.3851 mL20.7702 mL103.8508 mL
DMSO/DMF
1mg5mg10mg50mg
5 mM0.4154 mL2.0770 mL4.1540 mL20.7702 mL
10 mM0.2077 mL1.0385 mL2.0770 mL10.3851 mL
20 mM0.1039 mL0.5193 mL1.0385 mL5.1925 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

CAY 10730CAY10730CAY-10730
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