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(S)-Indoximod

Name: (S)-Indoximod
Brand: TargetMol
SKU: T3S1967
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S1967Cas No. 21339-55-9

Alias N-ME-Tryptophan, L-Abrine, 1-Methyl-L-tryptophan

(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse LLC cells at 200 mg/kg, induction of IDO1 protein expression in tumor of C57BL/6 mouse allografted with mouse LLC cells at 200 mg/kg, antitumor activity against mouse LLC cells allografted in C57BL/6 mouse, antiproliferative activity against mouse LLC cells at 50 uM.

(S)-Indoximod

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Purity: 99.69%

Catalog No. T3S1967Alias N-ME-Tryptophan, L-Abrine, 1-Methyl-L-tryptophanCas No. 21339-55-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$33	-	In Stock

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Purity:99.69%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

(S)-Indoximod AI Summary

(S)-Indoximod exhibits significant bioactivity as an inhibitor of the enzyme indoleamine 2,3-dioxygenase 1 (IDO1). This molecule has demonstrated inhibitory effects in various assays and model systems. Inhibitory concentration (IC50) values for (S)-Indoximod range widely depending on the experimental conditions, including 18400 nM in human HEK293 cells, 37000 nM for human IDO1, and 380000 nM in purified recombinant assays. Ki values, indicating its binding affinity, also vary, such as 6600 nM in spectrophotometric assays against human IDO1, and up to 53200 nM under aerobic conditions. Additionally, it exhibits antitumor activity in mouse models with a noted reduction in tumor volume, and shows low cytotoxicity with LD50 values greater than 1000 µM in mouse IDO-expressing cells. (S)-Indoximod also targets tryptophan 2,3-dioxygenase (TDO) and dihydrofolate reductase (DHFR), though with varied specificity and potency, thereby illustrating its broad potential in modulating immune responses and anti-cancer therapies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse LLC cells at 200 mg/kg, induction of IDO1 protein expression in tumor of C57BL/6 mouse allografted with mouse LLC cells at 200 mg/kg, antitumor activity against mouse LLC cells allografted in C57BL/6 mouse, antiproliferative activity against mouse LLC cells at 50 uM.
Targets&IC50	IDO:3-Dioxygenase
Synonyms	N-ME-Tryptophan, L-Abrine, 1-Methyl-L-tryptophan

Chemical Properties

Molecular Weight	218.25
Formula	C₁₂H₁₄N₂O₂
Cas No.	21339-55-9
Smiles	Cn1cc(C[C@H](N)C(O)=O)c2ccccc12
Relative Density.	1.28g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

0.1 M NaOH: 10 mg/mL (45.82 mM), Sonication is recommended.

DMSO: Slightly soluble

Solution Preparation Table

0.1 M NaOH

	1mg	5mg	10mg	50mg
1 mM	4.5819 mL	22.9095 mL	45.8190 mL	229.0951 mL
5 mM	0.9164 mL	4.5819 mL	9.1638 mL	45.8190 mL
10 mM	0.4582 mL	2.2910 mL	4.5819 mL	22.9095 mL
20 mM	0.2291 mL	1.1455 mL	2.2910 mL	11.4548 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc