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Rutaevin

🥰Excellent
Catalog No. TN2167Cas No. 33237-37-5

Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.

Rutaevin
Other Forms of Rutaevin:
Rutaevin 7-acetateTN492962306-81-4
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Rutaevin

🥰Excellent
Purity: 99.99%
Catalog No. TN2167Cas No. 33237-37-5
Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$63In StockIn Stock
5 mg$152In StockIn Stock
10 mg$228In StockIn Stock
25 mg$389In StockIn Stock
50 mg$572In StockIn Stock
1 mL x 10 mM (in DMSO)$177In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.99%
Appearance:Solid
Color:White
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.
In vitro
A new limonoid compound, named evorubodinin (1), was isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang (family Rutaceae), together with two known limonoid compounds, limonin (2) and evolimorutanin (3). The chemical structure of 1 was elucidated by spectroscopic method and single-crystal X-ray diffraction. The inhibitory effects of the isolated compounds 1-3 and the structurally related compounds evodol (4), shihulimonin A1 (5), evodirutaenin (6), 12α±-hydroxyRutaevin (7), and Rutaevin (8) on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages were also assayed[1]
Chemical Properties
Molecular Weight486.51
FormulaC26H30O9
Cas No.33237-37-5
SmilesC[C@]12[C@]34[C@](C)([C@@H](OC(=O)[C@]3(O4)[H])C=5C=COC5)CC[C@@]1([C@]67[C@](C(=O)[C@@H]2O)(C(C)(C)O[C@]6(CC(=O)OC7)[H])[H])[H]
Relative Density.1.44g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (123.33 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0555 mL10.2773 mL20.5546 mL102.7728 mL
5 mM0.4111 mL2.0555 mL4.1109 mL20.5546 mL
10 mM0.2055 mL1.0277 mL2.0555 mL10.2773 mL
20 mM0.1028 mL0.5139 mL1.0277 mL5.1386 mL
50 mM0.0411 mL0.2055 mL0.4111 mL2.0555 mL
100 mM0.0206 mL0.1028 mL0.2055 mL1.0277 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RutaevinReactiveOxygenSpeciesReactive Oxygen SpeciesRAW 264.7productionNOSynthaseNO SynthasemacrophageInhibitorinhibitEuodia rutaecarpa
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