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Rutaevin

Name: Rutaevin
Brand: TargetMol
SKU: TN2167
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. TN2167 Copy Product Info

Purity: 99.99%

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Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.

Rutaevin

Copy Product Info

😃Good

Catalog No. TN2167

Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.

Cas No. 33237-37-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$63	In Stock	In Stock
5 mg	$152	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$389	In Stock	In Stock
50 mg	$572	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$177	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.

In vitro

A new limonoid compound, named evorubodinin (1), was isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang (family Rutaceae), together with two known limonoid compounds, limonin (2) and evolimorutanin (3). The chemical structure of 1 was elucidated by spectroscopic method and single-crystal X-ray diffraction. The inhibitory effects of the isolated compounds 1-3 and the structurally related compounds evodol (4), shihulimonin A1 (5), evodirutaenin (6), 12α±-hydroxyRutaevin (7), and Rutaevin (8) on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages were also assayed[1]

Chemical Properties

Molecular Weight	486.51
Formula	C₂₆H₃₀O₉
Cas No.	33237-37-5
Smiles	C[C@]12[C@]34[C@](C)([C@@H](OC(=O)[C@]3(O4)[H])C=5C=COC5)CC[C@@]1([C@]67[C@](C(=O)[C@@H]2O)(C(C)(C)O[C@]6(CC(=O)OC7)[H])[H])[H]
Relative Density.	1.44g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (123.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0555 mL	10.2773 mL	20.5546 mL	102.7728 mL
5 mM	0.4111 mL	2.0555 mL	4.1109 mL	20.5546 mL
10 mM	0.2055 mL	1.0277 mL	2.0555 mL	10.2773 mL
20 mM	0.1028 mL	0.5139 mL	1.0277 mL	5.1386 mL
50 mM	0.0411 mL	0.2055 mL	0.4111 mL	2.0555 mL
100 mM	0.0206 mL	0.1028 mL	0.2055 mL	1.0277 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc