Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active inhibitor targeting both PTPN2 and PTPN1B, displaying potent IC50 values at 4.4 nM for PTPN2 and 1-10 nM for PTPN1B, respectively [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,970.00 | |
50 mg | 8-10 weeks | $ 2,580.00 | |
100 mg | 8-10 weeks | $ 3,400.00 |
Description | Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active inhibitor targeting both PTPN2 and PTPN1B, displaying potent IC50 values at 4.4 nM for PTPN2 and 1-10 nM for PTPN1B, respectively [1]. |
In vitro | Tegeprotafib (Compound 124; 5 days) inhibits IFNγ (0.5 ng/mL)-induced growth of B16F10 cells, achieving a growth inhibition rate of 60-90% at 33 μM [1]. |
In vivo | Tegeprotafib (Compound 124; 300 mg/kg; oral; BID for 21 days) exhibited antitumor activity in mice [1]. |
Synonyms | PTPN2/1-IN-1 |
Molecular Weight | 326.3 |
Formula | C13H11FN2O5S |
CAS No. | 2407610-46-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Tegeprotafib 2407610-46-0 Metabolism Phosphatase PTPN2/1-IN-1 inhibitor inhibit