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Tegeprotafib

Name: Tegeprotafib
Brand: TargetMol
SKU: T79049
Price: 428 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T79049Cas No. 2407610-46-0

Alias PTPN2/1-IN-1

Tegeprotafib (PTPN2/1-IN-1) is an orally active and potent PTPN1/2 inhibitor with potential anticancer and antitumor activity for the study of cancer and immune system diseases.

Tegeprotafib

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Purity: 99.69%

Catalog No. T79049Alias PTPN2/1-IN-1Cas No. 2407610-46-0

Tegeprotafib (PTPN2/1-IN-1) is an orally active and potent PTPN1/2 inhibitor with potential anticancer and antitumor activity for the study of cancer and immune system diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$428	-	In Stock
5 mg	$959	-	In Stock
10 mg	$1,280	-	In Stock
25 mg	$1,950	-	In Stock
50 mg	$2,550	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.69%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Tegeprotafib (PTPN2/1-IN-1) is an orally active and potent PTPN1/2 inhibitor with potential anticancer and antitumor activity for the study of cancer and immune system diseases.
In vitro	Tegeprotafib, treated for 5 days, was able to inhibit IFNγ (0.5 ng/mL)-induced proliferation of B16F10 cells, achieving 60-90% inhibition at a concentration of 33 μM. [1]
In vivo	300 mg/kg Tegeprotafib administered orally twice daily for 21 days showed anti-tumor effects in mice. [1]
Synonyms	PTPN2/1-IN-1

Chemical Properties

Molecular Weight	326.3
Formula	C₁₃H₁₁FN₂O₅S
Cas No.	2407610-46-0
Smiles	O=C1NS(=O)(=O)N(C=2C(O)=CC3=CC=C(OC)C=C3C2F)C1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (245.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0647 mL	15.3233 mL	30.6466 mL	153.2332 mL
5 mM	0.6129 mL	3.0647 mL	6.1293 mL	30.6466 mL
10 mM	0.3065 mL	1.5323 mL	3.0647 mL	15.3233 mL
20 mM	0.1532 mL	0.7662 mL	1.5323 mL	7.6617 mL
50 mM	0.0613 mL	0.3065 mL	0.6129 mL	3.0647 mL
100 mM	0.0306 mL	0.1532 mL	0.3065 mL	1.5323 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc