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DIDS sodium salt

Name: DIDS sodium salt
Brand: TargetMol
SKU: T18975
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: MDL101114ZA) Copy Product Info

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Synonyms: MDL101114ZA

Catalog No. T18975 Copy Product Info

Purity: 99.34%

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DIDS sodium salt (MDL101114ZA) is a small molecule inhibitor that acts as a dual-target inhibitor of both ABCA1 and VDAC1, suppressing RAD51-mediated homologous recombination. This compound inhibits anion exchange and Caspase-3/-9 activation, and is used in cancer research.

Cas No. 67483-13-0

Pack Size	Price	USA Stock	Global Stock
10 mg	$33	In Stock	In Stock
25 mg	$51	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.34%

Color:White to Yellow

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	DIDS sodium salt (MDL101114ZA) is a small molecule inhibitor that acts as a dual-target inhibitor of both ABCA1 and VDAC1, suppressing RAD51-mediated homologous recombination. This compound inhibits anion exchange and Caspase-3/-9 activation, and is used in cancer research.
Targets & IC50	RAD51:2 μM (KD), ClC-Ka chloride channel:100 μM, Cl⁻ uptake (neuroblastoma cells):150 nM
In vitro	Methods: In human peripheral blood mononuclear cells and RAW264.7 cells, whole-cell patch-clamp recordings were performed. After activation of volume-activated chloride channels (VACC) by hypotonic solution, 100 μM DIDS sodium salt was applied by perfusion. Results: DIDS sodium salt rapidly inhibited VACC currents without affecting the current-voltage relationship.[1]
Synonyms	MDL101114ZA
Cell Research	Instructions a. Solution preparation: Dissolve DIDS sodium salt (MDL101114ZA) in DMSO to prepare a 100 mmol/L storage solution, store it in aliquots at -20℃ or -80℃, and store it at 4℃ for future use. b. Operation steps: Dilute the storage solution to 100 µmol/L before use and add it to the cells for incubation. The above information is based on published literature. Experimental procedures should be appropriately modified to meet specific research demands.

Chemical Properties

Molecular Weight	498.5
Formula	C₁₆H₈N₂Na₂O₆S₄
Cas No.	67483-13-0
Smiles	O.[Na+].[Na+].[O-]S(=O)(=O)c1cc(ccc1C=Cc1ccc(cc1S([O-])(=O)=O)N=C=S)N=C=S
Relative Density.	1.54g/cm3

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125.3 mg/mL (251.35 mM), Sonication and heating are recommended.

H2O: 9.09 mg/mL (18.23 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0060 mL	10.0301 mL	20.0602 mL	100.3009 mL
5 mM	0.4012 mL	2.0060 mL	4.0120 mL	20.0602 mL
10 mM	0.2006 mL	1.0030 mL	2.0060 mL	10.0301 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1003 mL	0.5015 mL	1.0030 mL	5.0150 mL
50 mM	0.0401 mL	0.2006 mL	0.4012 mL	2.0060 mL
100 mM	0.0201 mL	0.1003 mL	0.2006 mL	1.0030 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc