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Azelaoyl PAF
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Catalog No. T36180Cas No. 354583-69-0
Alias 1-Hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine
Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones with potency comparable to rosiglitazone. In atherosclerosis studies, Azelaoyl PAF promotes the uptake of oxidized low-density lipoprotein (oxLDL) by macrophages by upregulating CD36 expression. In fibroblasts from Friedreich's ataxia (FRDA) patients, Azelaoyl PAF significantly increased mRNA and protein levels of ferritin.
Azelaoyl PAF
😃Good
Catalog No. T36180Alias 1-Hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholineCas No. 354583-69-0
Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones with potency comparable to rosiglitazone. In atherosclerosis studies, Azelaoyl PAF promotes the uptake of oxidized low-density lipoprotein (oxLDL) by macrophages by upregulating CD36 expression. In fibroblasts from Friedreich's ataxia (FRDA) patients, Azelaoyl PAF significantly increased mRNA and protein levels of ferritin.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | TBD | 35 days | |
| 1 mg | TBD | 35 days | |
| 5 mg | TBD | 35 days | |
| 10 mg | TBD | 35 days |
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CitedSelect Batch
Concentration:5.0 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones with potency comparable to rosiglitazone. In atherosclerosis studies, Azelaoyl PAF promotes the uptake of oxidized low-density lipoprotein (oxLDL) by macrophages by upregulating CD36 expression. In fibroblasts from Friedreich's ataxia (FRDA) patients, Azelaoyl PAF significantly increased mRNA and protein levels of ferritin. |
| In vitro | Methods: Human neuroblastoma cells SKNBE and primary fibroblasts from skin biopsies of patients with Friedreich's ataxia (FRDA) and healthy controls were treated with the PPAR-γ agonist azelaoyl PAF. Results: Azelaoyl PAF significantly increased intracellular frataxin levels by two-fold in the neuroblastoma cell line SKNBE and fibroblasts from FRDA patients, and azelaoyl PAF increased frataxin via a transcriptional mechanism.[1] |
| Alias | 1-Hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine |
| Molecular Weight | 651.85 |
| Formula | C33H66NO9P |
| Cas No. | 354583-69-0 |
| Smiles | [C@@H](COP(OCC[N+](C)(C)C)(=O)[O-])(OC(CCCCCCCC(O)=O)=O)COCCCCCCCCCCCCCCCC |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | Ethanol: 10.00 mg/mL (15.34 mM), Sonication is recommended. PBS (pH 7.2): 6.00 mg/mL (9.20 mM), Sonication is recommended. DMSO: 6.00 mg/mL (9.20 mM), Sonication is recommended. DMF: 20.00 mg/mL (30.68 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
PBS (pH 7.2)/DMSO/Ethanol/DMF
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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