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Azelaoyl PAF
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Catalog No. T36180Cas No. 354583-69-0
Alias 1-Hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine
Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones with potency comparable to rosiglitazone. In atherosclerosis studies, Azelaoyl PAF promotes the uptake of oxidized low-density lipoprotein (oxLDL) by macrophages by upregulating CD36 expression. In fibroblasts from Friedreich's ataxia (FRDA) patients, Azelaoyl PAF significantly increased mRNA and protein levels of ferritin.
Azelaoyl PAF
😃Good
Catalog No. T36180Alias 1-Hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholineCas No. 354583-69-0
Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones with potency comparable to rosiglitazone. In atherosclerosis studies, Azelaoyl PAF promotes the uptake of oxidized low-density lipoprotein (oxLDL) by macrophages by upregulating CD36 expression. In fibroblasts from Friedreich's ataxia (FRDA) patients, Azelaoyl PAF significantly increased mRNA and protein levels of ferritin.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 μg | $168 | 35 days | 35 days | |
| 1 mg | $316 | 35 days | 35 days | |
| 5 mg | $1,270 | 35 days | 35 days | |
| 10 mg | $2,180 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones with potency comparable to rosiglitazone. In atherosclerosis studies, Azelaoyl PAF promotes the uptake of oxidized low-density lipoprotein (oxLDL) by macrophages by upregulating CD36 expression. In fibroblasts from Friedreich's ataxia (FRDA) patients, Azelaoyl PAF significantly increased mRNA and protein levels of ferritin. |
| In vitro | Methods: Human neuroblastoma cells SKNBE and primary fibroblasts from skin biopsies of patients with Friedreich's ataxia (FRDA) and healthy controls were treated with the PPAR-γ agonist azelaoyl PAF. Results: Azelaoyl PAF significantly increased intracellular frataxin levels by two-fold in the neuroblastoma cell line SKNBE and fibroblasts from FRDA patients, and azelaoyl PAF increased frataxin via a transcriptional mechanism.[1] |
| Synonyms | 1-Hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine |
| Molecular Weight | 651.85 |
| Formula | C33H66NO9P |
| Cas No. | 354583-69-0 |
| Smiles | [C@@H](COP(OCC[N+](C)(C)C)(=O)[O-])(OC(CCCCCCCC(O)=O)=O)COCCCCCCCCCCCCCCCC |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
| Solubility Information | Ethanol: 10 mg/mL (15.34 mM), Sonication is recommended. PBS (pH 7.2): 6 mg/mL (9.2 mM), Sonication is recommended. DMSO: 6 mg/mL (9.2 mM), Sonication is recommended. DMF: 20 mg/mL (30.68 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
PBS (pH 7.2)/DMSO/Ethanol/DMF
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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