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LY2033298

Name: LY2033298
Brand: TargetMol
SKU: T27931
Price: 87 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27931Cas No. 886047-13-8

Alias LY-2033298, LY 2033298

LY2033298, a positive allosteric modulator of muscarine M4 receptor, enhances the inhibitory effect of oximoline on light-induced phase shift in circadian activity in hamsters and can be used in neurosystem-related diseases.

LY2033298

🥰Excellent

Purity: 99.06%

Catalog No. T27931Alias LY-2033298, LY 2033298Cas No. 886047-13-8

Pack Size	Price	Availability
1 mg	$87	In Stock
5 mg	$215	In Stock
10 mg	$365	In Stock
25 mg	$592	In Stock
50 mg	$857	In Stock
100 mg	$1,150	In Stock
200 mg	$1,550	In Stock

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Batch Information

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Purity:99.06%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	LY2033298, a positive allosteric modulator of muscarine M4 receptor, enhances the inhibitory effect of oximoline on light-induced phase shift in circadian activity in hamsters and can be used in neurosystem-related diseases.
In vivo	The M₄ positive allosteric modulator, LY2033298 (10-40 mg/kg), had no effect on light-induced phase shifts when administered alone, yet significantly enhanced (at 20 mg/kg) the inhibitory influence of oxotremorine on light-induced phase delays[1].
Synonyms	LY-2033298, LY 2033298

Chemical Properties

Molecular Weight	311.79
Formula	C₁₃H₁₄ClN₃O₂S
Cas No.	886047-13-8
Smiles	COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (160.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2073 mL	16.0364 mL	32.0729 mL	160.3643 mL
5 mM	0.6415 mL	3.2073 mL	6.4146 mL	32.0729 mL
10 mM	0.3207 mL	1.6036 mL	3.2073 mL	16.0364 mL
20 mM	0.1604 mL	0.8018 mL	1.6036 mL	8.0182 mL
50 mM	0.0641 mL	0.3207 mL	0.6415 mL	3.2073 mL
100 mM	0.0321 mL	0.1604 mL	0.3207 mL	1.6036 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc