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CDK12-IN-5

Name: CDK12-IN-5
Brand: TargetMol
SKU: T40290
Price: 168 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40290Cas No. 2651200-35-8

CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.

CDK12-IN-5

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Purity: 99.37%

Catalog No. T40290Cas No. 2651200-35-8

CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$168	In Stock	In Stock
5 mg	$419	In Stock	In Stock
10 mg	$679	In Stock	In Stock
25 mg	$1,390	In Stock	In Stock
50 mg	$2,190	In Stock	In Stock
100 mg	$2,970	-	In Stock
1 mL x 10 mM (in DMSO)	$463	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.37%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.
Targets&IC50	CDK12:23.9 nM, CDK9-cyclinT1:127 μM, CDK2-CyclinE:173 μM
In vitro	CDK12-IN-5 (Example 426) selectively suppresses BRCA1 mRNA levels in MDA-MB-231 cells (IC50 = 3.23 nM) without affecting CAL-120 cells. It exhibits antiproliferative effects on both MDA-MB-231 (IC50 = 4.19 nM) and CAL-120 cells (IC50 = 3.57 nM). Additionally, CDK12-IN-5 demonstrates high selectivity for CDK12 inhibition with an IC50 to DC50 CDK12 ratio of 32[1].

Chemical Properties

Molecular Weight	454.36
Formula	C₁₈H₁₅F₅N₈O
Cas No.	2651200-35-8
Smiles	FC=1C=CC=2N=C(NC2C1F)CNC3=NC(=NC4=C(C=NN34)C(F)(F)F)N5CCOCC5
Relative Density.	1.77 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (220.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2009 mL	11.0045 mL	22.0090 mL	110.0449 mL
5 mM	0.4402 mL	2.2009 mL	4.4018 mL	22.0090 mL
10 mM	0.2201 mL	1.1004 mL	2.2009 mL	11.0045 mL
20 mM	0.1100 mL	0.5502 mL	1.1004 mL	5.5022 mL
50 mM	0.0440 mL	0.2201 mL	0.4402 mL	2.2009 mL
100 mM	0.0220 mL	0.1100 mL	0.2201 mL	1.1004 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc