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VU 0469650

Name: VU 0469650
Brand: TargetMol
SKU: T29118
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29118Cas No. 1443748-47-7

Alias VU-0469650, VU0469650

VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).

VU 0469650

🥰Excellent

Purity: 98.03%

Catalog No. T29118Alias VU-0469650, VU0469650Cas No. 1443748-47-7

VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).

Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$76	In Stock
10 mg	$116	In Stock
25 mg	$233	In Stock
50 mg	$347	In Stock
100 mg	$515	In Stock
200 mg	$712	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock

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Batch Information

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Purity:98.03%

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Bioactivity

Description	VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).
Targets&IC50	mGlu1:99 nM
In vivo	VU 0469650 (10 mg/kg; I.P.; once; male Sprague-Dawley rats) shows an excellent selectivity profile and good exposure in both plasma and brain samples.[1] VU 0469650 (0.2 mg/kg; I.V.; once; male Sprague-Dawley rats) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour.[1]
Synonyms	VU-0469650, VU0469650

Chemical Properties

Molecular Weight	364.48
Formula	C₂₂H₂₈N₄O
Cas No.	1443748-47-7
Smiles	C(=O)(C12CC3CC(C1)CC(C2)C3)N4[C@H](C)CN(CC4)C5=C(C#N)N=CC=C5
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 45 mg/mL (123.46 mM), Sonication is recommended.

DMSO: 90 mg/mL (246.93 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7436 mL	13.7182 mL	27.4363 mL	137.1817 mL
5 mM	0.5487 mL	2.7436 mL	5.4873 mL	27.4363 mL
10 mM	0.2744 mL	1.3718 mL	2.7436 mL	13.7182 mL
20 mM	0.1372 mL	0.6859 mL	1.3718 mL	6.8591 mL
50 mM	0.0549 mL	0.2744 mL	0.5487 mL	2.7436 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3718 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc