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VU 0469650

Name: VU 0469650
Brand: TargetMol
SKU: T29118
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29118Cas No. 1443748-47-7

Alias VU-0469650, VU0469650

VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).

VU 0469650

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Purity: 98.03%

Catalog No. T29118Alias VU-0469650, VU0469650Cas No. 1443748-47-7

VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$37	-	In Stock
5 mg	$76	-	In Stock
10 mg	$116	-	In Stock
25 mg	$233	-	In Stock
50 mg	$347	-	In Stock
100 mg	$515	-	In Stock
200 mg	$712	-	In Stock
1 mL x 10 mM (in DMSO)	$87	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.03%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).
Targets&IC50	mGlu1:99 nM
In vivo	VU 0469650 (10 mg/kg; I.P.; once; male Sprague-Dawley rats) shows an excellent selectivity profile and good exposure in both plasma and brain samples.[1] VU 0469650 (0.2 mg/kg; I.V.; once; male Sprague-Dawley rats) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour.[1]
Synonyms	VU-0469650, VU0469650

Chemical Properties

Molecular Weight	364.48
Formula	C₂₂H₂₈N₄O
Cas No.	1443748-47-7
Smiles	C(=O)(C12CC3CC(C1)CC(C2)C3)N4[C@H](C)CN(CC4)C5=C(C#N)N=CC=C5
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 45 mg/mL (123.46 mM), Sonication is recommended.

DMSO: 90 mg/mL (246.93 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7436 mL	13.7182 mL	27.4363 mL	137.1817 mL
5 mM	0.5487 mL	2.7436 mL	5.4873 mL	27.4363 mL
10 mM	0.2744 mL	1.3718 mL	2.7436 mL	13.7182 mL
20 mM	0.1372 mL	0.6859 mL	1.3718 mL	6.8591 mL
50 mM	0.0549 mL	0.2744 mL	0.5487 mL	2.7436 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3718 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc