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Anti-HIF-2 alpha Polyclonal Antibody
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Catalog No. TMAB-00859
Alias PASD2, PAS domain-containing protein 2, MOP2, MOP 2, Member of pas superfamily 2, Member of PAS protein 2, Hypoxia inducible factor 2 alpha subunit, Hypoxia inducible factor 2 alpha, HLF, HIF2-alpha, HIF-2-alpha, HIF2A, HIF-1-alpha-like factor, EPAS1, EPAS 1, Endothelial PAS domain-containing protein 1, Endothelial PAS domain containing protein 1, ECYT4, Class E basic helix-loop-helix protein 73, bHLHe73, Basic helix loop helix PAS protein MOP2
Anti-HIF-2 alpha Polyclonal Antibody is a Rabbit antibody targeting HIF-2 alpha. Anti-HIF-2 alpha Polyclonal Antibody can be used in FCM,ICC/IF,WB.
Anti-HIF-2 alpha Polyclonal Antibody
Anti-HIF-2 alpha Polyclonal Antibody
😃Good
Catalog No. TMAB-00859Alias PASD2, PAS domain-containing protein 2, MOP2, MOP 2, Member of pas superfamily 2, Member of PAS protein 2, Hypoxia inducible factor 2 alpha subunit, Hypoxia inducible factor 2 alpha, HLF, HIF2-alpha, HIF-2-alpha, HIF2A, HIF-1-alpha-like factor, EPAS1, EPAS 1, Endothelial PAS domain-containing protein 1, Endothelial PAS domain containing protein 1, ECYT4, Class E basic helix-loop-helix protein 73, bHLHe73, Basic helix loop helix PAS protein MOP2
Anti-HIF-2 alpha Polyclonal Antibody is a Rabbit antibody targeting HIF-2 alpha. Anti-HIF-2 alpha Polyclonal Antibody can be used in FCM,ICC/IF,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $221 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-HIF-2 alpha Polyclonal Antibody is a Rabbit antibody targeting HIF-2 alpha. Anti-HIF-2 alpha Polyclonal Antibody can be used in FCM,ICC/IF,WB. |
| Synonyms | PASD2, PAS domain-containing protein 2, MOP2, MOP 2, Member of pas superfamily 2, Member of PAS protein 2, Hypoxia inducible factor 2 alpha subunit, Hypoxia inducible factor 2 alpha, HLF, HIF2-alpha, HIF-2-alpha, HIF2A, HIF-1-alpha-like factor, EPAS1, EPAS 1, Endothelial PAS domain-containing protein 1, Endothelial PAS domain containing protein 1, ECYT4, Class E basic helix-loop-helix protein 73, bHLHe73, Basic helix loop helix PAS protein MOP2 |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human) |
| Verified Activity | 25 μg total protein per Lane of various lysates probed with HIF 2 alpha polyclonal antibody, unconjugated (TMAB-00859) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000; ICC/IF: 1:50-200; FCM: 1:20-100 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus (Potential). |
| Tissue Specificity | Expressed in most tissues, with highest levels in lung, followed by heart, kidney, brain and liver. Predominantly expressed in endothelial cells. Also found in smooth muscle cells of the uterus, neurons, and brown adipose tissue. High expression in embryo |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. |
| Immunogen | KLH conjugated synthetic peptide: mouse HIF 2 Alpha |
| Antigen Species | Mouse |
| Gene Name | EPAS1 |
| Gene ID | |
| Protein Name | Endothelial PAS domain-containing protein 1 |
| Uniprot ID | |
| Biology Area | Response to hypoxia,HIF,HIF,HIF,HLH,Mitochondrial transcription,Hypoxia |
| Function | Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. |
| Molecular Weight | Theoretical: 96 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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