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Des His1, Glu8 Exendin-4

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Catalog No. T76291

Des His1, Glu8 Exendin-4 is a glucagon-like peptide-1 receptor (GLP-1-R) antagonist that regulates blood glucose. Des His1, Glu8 Exendin-4 is used in the study of diabetes and obesity.

Des His1, Glu8 Exendin-4

Des His1, Glu8 Exendin-4

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Purity: 99.92%
Catalog No. T76291
Des His1, Glu8 Exendin-4 is a glucagon-like peptide-1 receptor (GLP-1-R) antagonist that regulates blood glucose. Des His1, Glu8 Exendin-4 is used in the study of diabetes and obesity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$148In StockIn Stock
5 mg$326In StockIn Stock
10 mg$488In StockIn Stock
25 mg$828In StockIn Stock
50 mg$1,230In StockIn Stock
100 mg$1,670-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.92%
Appearance:Solid
Color:White
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COA HPLC MS

Product Introduction

Bioactivity
Description
Des His1, Glu8 Exendin-4 is a glucagon-like peptide-1 receptor (GLP-1-R) antagonist that regulates blood glucose. Des His1, Glu8 Exendin-4 is used in the study of diabetes and obesity.
In vivo
After third ventricle injection of Des His1, Glu8 Exendin-4 (50 μg, 2 μl/15 s), a hyperglycemic response was observed in rats for the first 45 minutes after the intraperitoneal glucose load, and there was a significant increase in insulin levels and insulin area under the curve (AUC) during the IVGTT[1].
Chemical Properties
Molecular Weight4063.46
FormulaC179H277N47O59S
Smiles[H]NCC(N[C@H](C(NCC(N[C@]([H])(C(N[C@@H](CC1=CC=CC=C1)C(N[C@]([H])(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@]([H])(C(N[C@H](C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(NCC(N[C@@H](C)C(N6CCC[C@H]6C(N7CCC[C@H]7C(N8CCC[C@H]8C(N[C@H](C(N)=O)CO)=O)=O)=O)=O)=O)=O)CO)=O)CO)=O)=O)=O)=O)CC(N)=O)=O)CCCCN)=O)CC(C)C)=O)=O)CCC(O)=O)=O)[C@@H](C)CC)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)C(C)C)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)CCCCN)=O)CO)=O)CC(C)C)=O)CCC(O)=O)=O)CO)=O)[C@H](O)C)=O)=O)[C@H](O)C)=O)=O)CCC(O)=O)=O
SequenceGly-Glu-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser
Sequence ShortGEGTFTSELSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

GlucagonReceptorGlucagon ReceptorGLP-1
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