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ING-1 (Synonyms: heMab)
Catalog No. T9901A-1904 Copy Product Info
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ING-1 (heMab) is a high-affinity humanized monoclonal antibody targeting the epithelial cell adhesion molecule (Ep-CAM). This compound acts as a transmembrane glycoprotein mediated by Ca2+. ING-1 binds to Ep-CAM on tumor cells, demonstrating potent in vitro activity to target and inhibit tumor growth and metastasis in mouse cancer models. It is applicable for research in cancers such as breast, colorectal, and lung cancers.
ING-1
Copy Product Info🥰Excellent
Catalog No. T9901A-1904
Synonyms heMab
ING-1 (heMab) is a high-affinity humanized monoclonal antibody targeting the epithelial cell adhesion molecule (Ep-CAM). This compound acts as a transmembrane glycoprotein mediated by Ca2+. ING-1 binds to Ep-CAM on tumor cells, demonstrating potent in vitro activity to target and inhibit tumor growth and metastasis in mouse cancer models. It is applicable for research in cancers such as breast, colorectal, and lung cancers.
ING-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Chemical Properties
Storage & Solubility Information
| Description | ING-1 (heMab) is a high-affinity humanized monoclonal antibody targeting the epithelial cell adhesion molecule (Ep-CAM). This compound acts as a transmembrane glycoprotein mediated by Ca2+. ING-1 binds to Ep-CAM on tumor cells, demonstrating potent in vitro activity to target and inhibit tumor growth and metastasis in mouse cancer models. It is applicable for research in cancers such as breast, colorectal, and lung cancers. |
| In vitro | ING-1 competes for binding with radiolabeled chimeric ING-1 to Ep-CAM in HT-29 human cells, with a Kd value ranging from 2 to 5 nM over 0.1-10000 nM at 4℃ for 5 hours. Additionally, ING-1 induces concentration-dependent lysis of 51 Cr-labeled BT-20, MCF-7, HT-29, CACO-2, NCI-H1568, PC-3, and HPAF-II cells in ADCC and CDC activity assays at 37℃ for 4 hours. |
| In vivo | Administering ING-1 (at 0.1-1.0 mg/kg via intravenous injection, twice weekly for three weeks) effectively reduces tumor size and metastasis in xenograft nude mouse models of HT-29 and PC-3. |
| Synonyms | heMab |
| Storage | Store at low temperature | Store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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