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ING-1

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Catalog No. T9901A-1904
Alias heMab

ING-1 (heMab) is a high-affinity humanized monoclonal antibody targeting the epithelial cell adhesion molecule (Ep-CAM). This compound acts as a transmembrane glycoprotein mediated by Ca2+. ING-1 binds to Ep-CAM on tumor cells, demonstrating potent in vitro activity to target and inhibit tumor growth and metastasis in mouse cancer models. It is applicable for research in cancers such as breast, colorectal, and lung cancers.

ING-1

ING-1

😃Good
Catalog No. T9901A-1904Alias heMab
ING-1 (heMab) is a high-affinity humanized monoclonal antibody targeting the epithelial cell adhesion molecule (Ep-CAM). This compound acts as a transmembrane glycoprotein mediated by Ca2+. ING-1 binds to Ep-CAM on tumor cells, demonstrating potent in vitro activity to target and inhibit tumor growth and metastasis in mouse cancer models. It is applicable for research in cancers such as breast, colorectal, and lung cancers.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Instruction Manual of Inhibitory Antibody

Product Introduction

Bioactivity
Description
ING-1 (heMab) is a high-affinity humanized monoclonal antibody targeting the epithelial cell adhesion molecule (Ep-CAM). This compound acts as a transmembrane glycoprotein mediated by Ca2+. ING-1 binds to Ep-CAM on tumor cells, demonstrating potent in vitro activity to target and inhibit tumor growth and metastasis in mouse cancer models. It is applicable for research in cancers such as breast, colorectal, and lung cancers.
In vitro
ING-1 competes for binding with radiolabeled chimeric ING-1 to Ep-CAM in HT-29 human cells, with a Kd value ranging from 2 to 5 nM over 0.1-10000 nM at 4℃ for 5 hours. Additionally, ING-1 induces concentration-dependent lysis of 51 Cr-labeled BT-20, MCF-7, HT-29, CACO-2, NCI-H1568, PC-3, and HPAF-II cells in ADCC and CDC activity assays at 37℃ for 4 hours.
In vivo
Administering ING-1 (at 0.1-1.0 mg/kg via intravenous injection, twice weekly for three weeks) effectively reduces tumor size and metastasis in xenograft nude mouse models of HT-29 and PC-3.
SynonymsheMab
Chemical Properties
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Related Tags: buy ING-1 | purchase ING-1 | ING-1 cost | order ING-1 | ING-1 in vivo | ING-1 in vitro
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