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Pentoxyverine

Name: Pentoxyverine
Brand: TargetMol
SKU: T22284
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22284Cas No. 77-23-6

Alias Carbetapentane

Pentoxyverine (Carbetapentan) is an orally available cough suppressant, an antagonist of muscarinic receptor M1 and an agonist of the σ1 receptor, which causes alveolar relaxation and thus symptomatic relief.

Pentoxyverine

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Purity: 97.11%

Catalog No. T22284Alias CarbetapentaneCas No. 77-23-6

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	In Stock	In Stock
25 mg	$61	In Stock	In Stock
50 mg	$87	In Stock	In Stock
100 mg	$125	-	In Stock
200 mg	$183	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.11%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Pentoxyverine (Carbetapentan) is an orally available cough suppressant, an antagonist of muscarinic receptor M1 and an agonist of the σ1 receptor, which causes alveolar relaxation and thus symptomatic relief.
Targets&IC50	σ1 receptor:75 nM (Ki)
In vitro	Pentoxyverine binds human σ₁ receptors with moderate affinity (Ki ~100-300 nM) and activates typical σ₁-mediated cellular responses such as calcium flux[1].
In vivo	Pentoxyverine (30-60 mg/kg, i.p.) exhibits antinociceptive effects in mice in thermal and inflammatory pain models. Pentoxyverine's effects are σ₁ receptor-dependent, as shown by partial reversal with σ₁ antagonist BD1047[1].
Synonyms	Carbetapentane

Chemical Properties

Molecular Weight	333.47
Formula	C₂₀H₃₁NO₃
Cas No.	77-23-6
Smiles	O=C(OCCOCCN(CC)CC)C1(C=2C=CC=CC2)CCCC1
Relative Density.	1.048 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (599.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9988 mL	14.9939 mL	29.9877 mL	149.9385 mL
5 mM	0.5998 mL	2.9988 mL	5.9975 mL	29.9877 mL
10 mM	0.2999 mL	1.4994 mL	2.9988 mL	14.9939 mL
20 mM	0.1499 mL	0.7497 mL	1.4994 mL	7.4969 mL
50 mM	0.0600 mL	0.2999 mL	0.5998 mL	2.9988 mL
100 mM	0.0300 mL	0.1499 mL	0.2999 mL	1.4994 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc