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Hydroxyzine dihydrochloride

Name: Hydroxyzine dihydrochloride
Brand: TargetMol
SKU: T2200
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2200Cas No. 2192-20-3

Alias Hydroxyzine 2HCl

Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

Hydroxyzine dihydrochloride

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Purity: 99.79%

Catalog No. T2200Alias Hydroxyzine 2HClCas No. 2192-20-3

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$29	In Stock	In Stock
500 mg	$35	In Stock	In Stock
1 g	$48	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.79%

Color:White

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Product Introduction

Bioactivity

Description	Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
Targets&IC50	H1 receptor:10 nM-19 nM
In vitro	In a tail-flick test, intraperitoneal injection of 12.5 mg/kg Hydroxyzine reduced the analgesic effect of morphine in rats; however, an injection of 50 mg/kg Hydroxyzine enhanced the effect of morphine. Furthermore, 500 μM Hydroxyzine significantly decreased the steady-state concentration of etoposide by half, achieving a concentration of 0.055 μM/mL in Sprague-Dawley rats.
In vivo	At a concentration of 0.1 mM, Hydroxyzine inhibits 50% of Experimental Autoimmune Encephalomyelitis (EAE) exacerbation in Lewis rats and suppresses 70% of mast cell degranulation. In bladder slices pre-treated with Hydroxyzine, a 60-minute incubation results in a 34% inhibition of 5-hydroxytryptamine release induced by 10 μM carbachol, with 1 μM Hydroxyzine causing a 25% inhibition and 0.1 μM suppressing it by 17%. Additionally, 500 μM Hydroxyzine significantly enhances the transport of digoxin to the serosal side in isolated everted jejunum sacs and notably reduces the efflux of approximately 2.4 μg/mL digoxin in the jejunum and ileum.
Synonyms	Hydroxyzine 2HCl

Chemical Properties

Molecular Weight	447.83
Formula	C₂₁H₂₇ClN₂O₂·2HCl
Cas No.	2192-20-3
Smiles	C1CN(CCN1CCOCCO)C(c1ccccc1)c1ccc(cc1)Cl.Cl.Cl
Relative Density.	1.182 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 201 mM, Sonication is recommended.

DMSO: 55 mg/mL (122.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2330 mL	11.1650 mL	22.3299 mL	111.6495 mL
5 mM	0.4466 mL	2.2330 mL	4.4660 mL	22.3299 mL
10 mM	0.2233 mL	1.1165 mL	2.2330 mL	11.1650 mL
20 mM	0.1116 mL	0.5582 mL	1.1165 mL	5.5825 mL
50 mM	0.0447 mL	0.2233 mL	0.4466 mL	2.2330 mL
100 mM	0.0223 mL	0.1116 mL	0.2233 mL	1.1165 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc