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Anti-ASGR1 Antibody (9O559)
😃Good
Catalog No. TMAY-01150
Alias HL-1, CLEC4H1, asialoglycoprotein receptor 1, ASGPR1, ASGPR
Anti-ASGR1 Antibody (9O559) is a Rabbit antibody targeting ASGR1. Anti-ASGR1 Antibody (9O559) can be used in ICC/IF.
Anti-ASGR1 Antibody (9O559)
Anti-ASGR1 Antibody (9O559)
😃Good
Catalog No. TMAY-01150Alias HL-1, CLEC4H1, asialoglycoprotein receptor 1, ASGPR1, ASGPR
Anti-ASGR1 Antibody (9O559) is a Rabbit antibody targeting ASGR1. Anti-ASGR1 Antibody (9O559) can be used in ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-ASGR1 Antibody (9O559) is a Rabbit antibody targeting ASGR1. Anti-ASGR1 Antibody (9O559) can be used in ICC/IF. |
| Alias | HL-1, CLEC4H1, asialoglycoprotein receptor 1, ASGPR1, ASGPR |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 9O559 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of ASGR1 in HepG2 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human ASGR1 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm. |
| Application | ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Asialoglycoprotein Receptor (rh Asialoglycoprotein Receptor; TMPY-02702; P07306; Gln62-Leu291). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Asialoglycoprotein Receptor Protein (TMPY-02702) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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