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(E/Z)-Necrosulfonamide

Name: (E/Z)-Necrosulfonamide
Brand: TargetMol
SKU: T7129
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7129Cas No. 432531-71-0

(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.

(E/Z)-Necrosulfonamide

🥰Excellent

Purity: 98%

Catalog No. T7129Cas No. 432531-71-0

(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$71	In Stock	In Stock
25 mg	$120	In Stock	In Stock
50 mg	$205	In Stock	In Stock
100 mg	$308	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Color:Yellow

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.
In vivo	Necrosulfonamide attenuates the spinal cord injury via necroptosis inhibition[1]
Animal Research	Pathologic condition was detected using hematoxylin-eosin staining on injured spinal cord and other major organs. Necroptosis-related factors-RIP1, RIP3, and MLKL-were detected using Western blot. Detections on mitochondrial functions such as adenosine triphosphate generation and activities of superoxide dismutase and caspase-3 were also performed. Finally, ethologic performance was detected using a 21-point open-field locomotion test[1].

Chemical Properties

Molecular Weight	461.47
Formula	C₁₈H₁₅N₅O₆S₂
Cas No.	432531-71-0
Smiles	COc1nccnc1NS(=O)(=O)c1ccc(NC(=O)C=Cc2ccc(s2)[N+]([O-])=O)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (54.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1670 mL	10.8349 mL	21.6699 mL	108.3494 mL
5 mM	0.4334 mL	2.1670 mL	4.3340 mL	21.6699 mL
10 mM	0.2167 mL	1.0835 mL	2.1670 mL	10.8349 mL
20 mM	0.1083 mL	0.5417 mL	1.0835 mL	5.4175 mL
50 mM	0.0433 mL	0.2167 mL	0.4334 mL	2.1670 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc