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Anti-NME1 Antibody-PE (1U277)
🥰Excellent
Catalog No. TMAY-01935P
Anti-NME1 Antibody-PE (1U277) is a PE-conjugated Mouse antibody targeting NME1. Anti-NME1 Antibody-PE (1U277) can be used in FCM.
Anti-NME1 Antibody-PE (1U277)
Anti-NME1 Antibody-PE (1U277)
🥰Excellent
Catalog No. TMAY-01935P
Anti-NME1 Antibody-PE (1U277) is a PE-conjugated Mouse antibody targeting NME1. Anti-NME1 Antibody-PE (1U277) can be used in FCM.
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Product Introduction
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Chemical Properties
| Description | Anti-NME1 Antibody-PE (1U277) is a PE-conjugated Mouse antibody targeting NME1. Anti-NME1 Antibody-PE (1U277) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 1U277 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human NME1 expression in HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Mouse anti-NME1. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NME1 / NDKA (rh NME1 / NDKA; TMPY-04467; NP_000260.1; Ala 2-Glu 152) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as CKI and Aurora-A/STK15. The second group of proteins acts as downstream effectors for the regulation of specific gene transcriptions, GTP-binding protein functions, and signal transduction in the Erk signal cascade. The third group of proteins can be classified as bi-directionally influencing binding partners of NM23-H1. As a result, the interactions with NM23-H1 and binding partners have implications in the biochemical characterization involved in metastasis and tumorigenesis. NDKA is increased in human postmortem cerebrospinal fluid (CSF), a model of global brain insult, suggesting that measurement in CSF and, more importantly, in plasma may be useful as a biomarker of stroke. Additionally, NM23-H1 significantly reduces metastasis without effects on primary tumor size and was the first discovered metastasis suppressor gene. |
| Conjucates | PE |
| Others Formats | Unconjugated/FITC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human NME1 / NDKA protein (TMPY-04467) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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