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Brolucizumab
🥰Excellent
Catalog No. T80593Cas No. 1531589-13-5
Alias RTH258, ESBA 1008, DLX1008
Brolucizumab (DLX1008) is a single-chain variable fragment (scFv) anti-VEGF-A antibody exhibiting an exceptionally low picomolar binding affinity (K D = 1.05 pM). through its potent blockade of vascular endothelial growth factor A (VEGF-A), Brolucizumab effectively reduces pathological neovascularization and vascular leakage within the macula and is under investigation for the treatment of neovascular (wet) age-related macular degeneration (AMD).
Brolucizumab
Brolucizumab
🥰Excellent
Purity: 95%
Catalog No. T80593Alias RTH258, ESBA 1008, DLX1008Cas No. 1531589-13-5
Brolucizumab (DLX1008) is a single-chain variable fragment (scFv) anti-VEGF-A antibody exhibiting an exceptionally low picomolar binding affinity (K D = 1.05 pM). through its potent blockade of vascular endothelial growth factor A (VEGF-A), Brolucizumab effectively reduces pathological neovascularization and vascular leakage within the macula and is under investigation for the treatment of neovascular (wet) age-related macular degeneration (AMD).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $813 | In Stock | |
| 5 mg | $2,270 | In Stock |
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Concentration:13.166 mg/mL
Purity:95%
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Product Introduction
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Chemical Properties
| Description | Brolucizumab (DLX1008) is a single-chain variable fragment (scFv) anti-VEGF-A antibody exhibiting an exceptionally low picomolar binding affinity (K D = 1.05 pM). through its potent blockade of vascular endothelial growth factor A (VEGF-A), Brolucizumab effectively reduces pathological neovascularization and vascular leakage within the macula and is under investigation for the treatment of neovascular (wet) age-related macular degeneration (AMD). |
| In vitro | Brolucizumab (2683 nM) inhibits VEGFR1 phosphorylation in VEGF-A112-induced U87MG human glioma cells and VEGFR2 phosphorylation in ZHE-483-2 GMECs. [1] |
| In vivo | Brolucizumab (15 mg/kg, intravenous injection, five days a week) was used to treat mSLK-KSHV xenografts and the tumor growth in vivo was observed. Results: Brolucizumab slowed the growth of mSLK-KSHV xenograft tumors. [2] |
| Synonyms | RTH258, ESBA 1008, DLX1008 |
| Cas No. | 1531589-13-5 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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