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GTP-14564

🥰Excellent
Catalog No. T71857Cas No. 34823-86-4

GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 μ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of Ba/F3 expressing wild-type FLT3. F3 expressing wild-type FLT3 (wt-FLT3).

GTP-14564

GTP-14564

🥰Excellent
Purity: 99.69%
Catalog No. T71857Cas No. 34823-86-4
GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 μ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of Ba/F3 expressing wild-type FLT3. F3 expressing wild-type FLT3 (wt-FLT3).
Pack SizePriceAvailabilityQuantity
2 mg$34In Stock
5 mg$59In Stock
10 mg$107In Stock
25 mg$218In Stock
50 mg$347In Stock
100 mg$500In Stock
200 mg$689In Stock
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Purity:99.69%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 μ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of Ba/F3 expressing wild-type FLT3. F3 expressing wild-type FLT3 (wt-FLT3).
Targets&IC50
PDGFRβ:1 µM, c-Kit:0.3 µM, c-Fms:0.3 µM, ITD-FLT3:0.3 µM
In vitro
GTP-14564 (1 μM) inhibited the growth of interleukin-3-independent Ba/F3 expressing ITD-FLT3, whereas a 30-fold higher concentration of GTP-14564 was required to inhibit FLT3 ligand-dependent growth of Ba/F3 expressing wild type FLT3 (wt-FLT3).[1]
Chemical Properties
Molecular Weight234.25
FormulaC15H10N2O
Cas No.34823-86-4
SmilesC12=C(C=3C(O1)=CC=CC3)NN=C2C4=CC=CC=C4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMF: 27 mg/mL (115.26 mM), Sonication is recommended.
DMSO: 60 mg/mL (256.14 mM), Sonication is recommended.
Solution Preparation Table
DMF/DMSO
1mg5mg10mg50mg
1 mM4.2689 mL21.3447 mL42.6894 mL213.4472 mL
5 mM0.8538 mL4.2689 mL8.5379 mL42.6894 mL
10 mM0.4269 mL2.1345 mL4.2689 mL21.3447 mL
20 mM0.2134 mL1.0672 mL2.1345 mL10.6724 mL
50 mM0.0854 mL0.4269 mL0.8538 mL4.2689 mL
100 mM0.0427 mL0.2134 mL0.4269 mL2.1345 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

TyrosineKinasesTyrosine KinasesGTP-14564GTP14564GTP 14564FLT3 (WT)FLT3 (ITD)
Related Tags: buy GTP-14564 | purchase GTP-14564 | GTP-14564 cost | order GTP-14564 | GTP-14564 chemical structure | GTP-14564 in vitro | GTP-14564 formula | GTP-14564 molecular weight
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