Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 μ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of Ba/F3 expressing wild-type FLT3. F3 expressing wild-type FLT3 (wt-FLT3).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 98.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 578.00 | |
100 mg | In stock | $ 833.00 | |
500 mg | In stock | $ 1,690.00 |
Description | GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 μ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of Ba/F3 expressing wild-type FLT3. F3 expressing wild-type FLT3 (wt-FLT3). |
Targets&IC50 | c-Fms:0.3 µM, ITD-FLT3:0.3 µM, c-Kit:0.3 µM, PDGFRβ:1 µM |
In vitro | GTP-14564 (1 μM) inhibited the growth of interleukin-3-independent Ba/F3 expressing ITD-FLT3, whereas a 30-fold higher concentration of GTP-14564 was required to inhibit FLT3 ligand-dependent growth of Ba/F3 expressing wild type FLT3 (wt-FLT3).[1] |
Molecular Weight | 234.25 |
Formula | C15H10N2O |
CAS No. | 34823-86-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 27.0 mg/mL (115.2 mM)
DMSO: 27.0 mg/mL (115.2 mM)
You can also refer to dose conversion for different animals. More
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GTP-14564 34823-86-4 Angiogenesis Tyrosine Kinase/Adaptors FLT Tyrosine Kinases GTP14564 GTP 14564 inhibitor inhibit