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GPI-1485

Name: GPI-1485
Brand: TargetMol
SKU: T9820
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9820Cas No. 186268-78-0

Alias GM1485

GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.

GPI-1485

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Purity: 99.80%

Catalog No. T9820Alias GM1485Cas No. 186268-78-0

GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	-	In Stock
5 mg	$135	-	In Stock
10 mg	$198	-	In Stock
25 mg	$378	-	In Stock
50 mg	$562	-	In Stock
100 mg	$795	-	In Stock
200 mg	$1,170	-	In Stock
1 mL x 10 mM (in DMSO)	$152	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.80%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.
In vitro	GPI-1485 induced cellular reprogramming and neural cell induction in normal human dermal fibroblasts (NHDF) [1].
In vivo	GPI-1485 (5 mg/kg; intraperitoneal injection; 6-week period of daily) improved long-term neurological recovery in rats
Synonyms	GM1485

Chemical Properties

Molecular Weight	241.28
Formula	C₁₂H₁₉NO₄
Cas No.	186268-78-0
Smiles	C(C(C(CC)(C)C)=O)(=O)N1[C@H](C(O)=O)CCC1
Relative Density.	1.188 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (393.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (13.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1446 mL	20.7228 mL	41.4456 mL	207.2281 mL
5 mM	0.8289 mL	4.1446 mL	8.2891 mL	41.4456 mL
10 mM	0.4145 mL	2.0723 mL	4.1446 mL	20.7228 mL
20 mM	0.2072 mL	1.0361 mL	2.0723 mL	10.3614 mL
50 mM	0.0829 mL	0.4145 mL	0.8289 mL	4.1446 mL
100 mM	0.0414 mL	0.2072 mL	0.4145 mL	2.0723 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc