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Fabomotizole

Name: Fabomotizole
Brand: TargetMol
SKU: T1864
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1864Cas No. 173352-21-1

Alias Obenoxazine, CM346

Fabomotizole (Obenoxazine) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.

Fabomotizole

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Purity: 99.4%

Catalog No. T1864Alias Obenoxazine, CM346Cas No. 173352-21-1

Fabomotizole (Obenoxazine) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$55	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$218	In Stock	In Stock
50 mg	$323	In Stock	In Stock
100 mg	$483	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.4%

Color:White

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COA HPLC HNMR LCMS

Product Introduction

Fabomotizole AI Summary

Fabomotizole exhibits multifaceted biological activities. It demonstrates antiviral efficacy against SARS-CoV-2 by reducing the cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM, with 3.86% and -0.09% inhibition respectively, measured after 48 hours of exposure. In SARS-CoV-2 3CL-Pro protease assays, it shows 2.938% inhibition at 20 µM. It also exhibits a hit score of 0.2029 in HRCE cell assays against the USA-WA1/2020 strain, which is below the threshold of 0.6. Additionally, Fabomotizole has demonstrated inhibitory activity on human HDAC6, with inhibition percentages of 21.13% using a commercial peptide substrate and 7.72% with a custom peptide substrate. Notably, it shows strong giardicidal activity against Giardia intestinalis, including metronidazole-resistant, albendazole-resistant, and nitazoxanide-resistant strains, with IC50 values ranging from 29.0 nM to 65.0 nM after 48 hours of incubation, making it a potential candidate for treating drug-resistant Giardia infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fabomotizole (Obenoxazine) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.
Synonyms	Obenoxazine, CM346

Chemical Properties

Molecular Weight	307.41
Formula	C₁₅H₂₁N₃O₂S
Cas No.	173352-21-1
Smiles	S(CCN1CCOCC1)C=2NC=3C(N2)=CC=C(OCC)C3
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (146.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2530 mL	16.2649 mL	32.5298 mL	162.6492 mL
5 mM	0.6506 mL	3.2530 mL	6.5060 mL	32.5298 mL
10 mM	0.3253 mL	1.6265 mL	3.2530 mL	16.2649 mL
20 mM	0.1626 mL	0.8132 mL	1.6265 mL	8.1325 mL
50 mM	0.0651 mL	0.3253 mL	0.6506 mL	3.2530 mL
100 mM	0.0325 mL	0.1626 mL	0.3253 mL	1.6265 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc