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Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody
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Catalog No. TMAC-01041
Alias p-CCND2 (Thr280), p-CCND2 (T280), CCND2 (p-Thr280), CCND2 (p-T280)
Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CCND2 (Thr280). Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody can be used in WB.
Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody
Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody
😃Good
Catalog No. TMAC-01041Alias p-CCND2 (Thr280), p-CCND2 (T280), CCND2 (p-Thr280), CCND2 (p-T280)
Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CCND2 (Thr280). Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $216 | 7-10 days | 7-10 days | |
| 100 μL | $318 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CCND2 (Thr280). Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody can be used in WB. |
| Synonyms | p-CCND2 (Thr280), p-CCND2 (T280), CCND2 (p-Thr280), CCND2 (p-T280) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of extracts from COLO cells, treated with EGF (200ng/ml, 30mins), using Cyclin D2 (Phospho-Thr280) antibody TMAC-01041. The lane on the right is treated with the synthesized peptide.  |
| Application | |
| Recommended Dose | WB: 1:500-3000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of threonine 280 (A-S-T(p)-P-T) derived from Human Cyclin D2 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 40 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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