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m-Chlorophenylbiguanide hydrochloride

Name: m-Chlorophenylbiguanide hydrochloride
Brand: TargetMol
SKU: T22959
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: 1-(3-Chlorophenyl)biguanidehydrochloride) Copy Product Info

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Synonyms: 1-(3-Chlorophenyl)biguanidehydrochloride

Catalog No. T22959 Copy Product Info

Purity: 99.87%

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m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist. m-Chlorophenylbiguanide hydrochloride selectively binds 5-HT3(Ki: 0.002 µM) over 5-HT1A(Ki: 10 µM) and 5-HT2(Ki: 10 µM) receptors but also binds to high and low affinity sites on the dopamine transporter(DAT; IC50s: 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes).

Cas No. 2113-05-5

Pack Size	Price	USA Stock	Global Stock	Quantity
500 mg	$29	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist. m-Chlorophenylbiguanide hydrochloride selectively binds 5-HT3(Ki: 0.002 µM) over 5-HT1A(Ki: 10 µM) and 5-HT2(Ki: 10 µM) receptors but also binds to high and low affinity sites on the dopamine transporter(DAT; IC50s: 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes).
Targets & IC50	5-HT1:10 µM(Ki), 5-HT2:10 µM(Ki), 5-HT3:0.002 µM(Ki)
In vivo	m-Chlorophenylbiguanide hydrochloride induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 μM, respectively).m-Chlorophenylbiguanide hydrochloride induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg)[1].
Synonyms	1-(3-Chlorophenyl)biguanidehydrochloride

Chemical Properties

Molecular Weight	248.11
Formula	C₈H₁₁Cl₂N₅
Cas No.	2113-05-5
Smiles	N\C(N)=N/C(=N)Nc1cccc(Cl)c1
Relative Density.	1.49g/cm3

Storage & Solubility Information

Storage

Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (503.81 mM), Sonication is recommended.

H2O: < 20 mg/mL (80.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 10 mg/mL (40.3 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0305 mL	20.1524 mL	40.3047 mL	201.5235 mL
5 mM	0.8061 mL	4.0305 mL	8.0609 mL	40.3047 mL
10 mM	0.4030 mL	2.0152 mL	4.0305 mL	20.1524 mL
20 mM	0.2015 mL	1.0076 mL	2.0152 mL	10.0762 mL
50 mM	0.0806 mL	0.4030 mL	0.8061 mL	4.0305 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0403 mL	0.2015 mL	0.4030 mL	2.0152 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

m-Chlorophenylbiguanide HydrochloridemChlorophenylbiguanide hydrochloridem Chlorophenylbiguanide hydrochloride5HTReceptor5-HT35HT Receptor

Related Tags: m-Chlorophenylbiguanide hydrochloride chemical structure | m-Chlorophenylbiguanide hydrochloride in vivo | m-Chlorophenylbiguanide hydrochloride formula | m-Chlorophenylbiguanide hydrochloride molecular weight