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SIRP beta 1 Protein, Human, Recombinant (His)

Catalog No. TMPJ-00252
Synonyms: CD172b, CD172 antigen-like family member B, Signal-regulatory protein beta-1, Signal-regulatory protein β-1, SIRP-β-1, SIRPB1, SIRP-beta-1

Signal-regulatory protein beta-1 (SIRPB1, CD172b) is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
SIRP beta 1 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 129.00
50 μg 5 days $ 390.00
500 μg 5 days $ 1,730.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description Signal-regulatory protein beta-1 (SIRPB1, CD172b) is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number O00241
Synonyms CD172b, CD172 antigen-like family member B, Signal-regulatory protein beta-1, Signal-regulatory protein β-1, SIRP-β-1, SIRPB1, SIRP-beta-1
Amino Acid Glu30-Glu362
Construction Recombinant Human Signal-regulatory Protein Beta-1 is produced by our Mammalian expression system and the target gene encoding Glu30-Glu362 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 45-55 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Signal-regulatory protein beta-1 (SIRPB1, CD172b) is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK.

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Keywords

SIRP beta 1 Protein, Human, Recombinant (His) CD172b CD172 antigen-like family member B Signal-regulatory protein b-1 Signal-regulatory protein beta-1 SIRPB-1 SIRPB 1 Signal-regulatory protein β-1 SIRP-β-1 SIRPB1 SIRP-beta-1 SIRP-b-1 recombinant recombinant-proteins proteins protein

 

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