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Chk1-IN-5

Name: Chk1-IN-5
Brand: TargetMol
SKU: T37098
Rating: 4.5 (1 reviews)

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Catalog No. T37098Cas No. 2120398-39-0

Alias Chk1-IN-5

Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].

Chk1-IN-5

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Catalog No. T37098Alias Chk1-IN-5Cas No. 2120398-39-0

Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$2,270	10-14 weeks	10-14 weeks
50 mg	$2,980	10-14 weeks	10-14 weeks
100 mg	$4,000	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].
In vitro	Chk1-IN-5 (compound 3; concentrations of 0.4, 1.2, 3.7, 11.1, 33.3, and 100 nM) effectively inhibits Chk1 phosphorylation in HT-29 colon cells[1].
In vivo	Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells. Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) demonstrates a longer half-life (T1/2=3.8 hours) and higher systemic exposure (CL=2.3 L/hr⋅kg; Vss=6.4 L/kg; AUC=4531 ng⋅ml⋅h)[1]. [Animal Model: Baib/c nude mice with HT-29 colon cancer cells][1].
Synonyms	Chk1-IN-5

Chemical Properties

Molecular Weight	383.38
Formula	C₁₈H₁₈FN₇O₂
Cas No.	2120398-39-0
Smiles	O(CCCN)C1=C(C(OC)=CC(F)=C1)C2=CC(NC=3C=NC(C#N)=CN3)=NN2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc